Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2399960..2400477 Replicon chromosome
Accession NZ_CP014022
Organism Staphylococcus lugdunensis strain FDAARGOS_141

Toxin (Protein)


Gene name mazF Uniprot ID A0A853V3R6
Locus tag AL499_RS11235 Protein ID WP_002461192.1
Coordinates 2400127..2400477 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A853V233
Locus tag AL499_RS11230 Protein ID WP_002461193.1
Coordinates 2399960..2400130 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL499_RS11205 2395785..2396267 + 483 WP_002492078.1 PH domain-containing protein -
AL499_RS11210 2396260..2397774 + 1515 WP_002492082.1 PH domain-containing protein -
AL499_RS11215 2397761..2398273 + 513 WP_002461197.1 PH domain-containing protein -
AL499_RS11220 2398285..2398677 + 393 WP_002461196.1 holo-ACP synthase -
AL499_RS11225 2398725..2399873 + 1149 WP_002492086.1 alanine racemase -
AL499_RS11230 2399960..2400130 + 171 WP_002461193.1 hypothetical protein Antitoxin
AL499_RS11235 2400127..2400477 + 351 WP_002461192.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
AL499_RS11240 2400911..2401912 + 1002 WP_002461191.1 PP2C family protein-serine/threonine phosphatase -
AL499_RS11245 2402003..2402329 + 327 WP_002461190.1 anti-sigma factor antagonist -
AL499_RS11250 2402331..2402810 + 480 WP_002492094.1 anti-sigma B factor RsbW -
AL499_RS11255 2402785..2403555 + 771 WP_002461188.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13079.20 Da        Isoelectric Point: 9.9784

>T59934 WP_002461192.1 NZ_CP014022:2400127-2400477 [Staphylococcus lugdunensis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIGKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSEDKMKEVDHALDISLGLHNYH

Download         Length: 351 bp

>T59934 NZ_CP014022:2400127-2400477 [Staphylococcus lugdunensis]
ATGATTAGACGCGGCGATGTATATTTAGCTGATTTATCACCGGTACAAGGGTCTGAACAAGGGGGAGTAAGACCAGTTGT
TATCATTCAAAATGACACCGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCAATTACTGGAAGGATTAATAAAGCGA
AAATACCCACTCATGTGGAAATAGGTAAAAAGAAATATAAGTTAGATAAAGATTCTGTTATTCTGTTAGAGCAAATACGA
ACATTAGATAAAAAAAGATTAAAAGAAAAACTTACTTATCTCTCTGAGGATAAAATGAAAGAAGTAGATCATGCCCTAGA
CATTAGTCTAGGTTTACATAACTATCATTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6327.92 Da        Isoelectric Point: 4.0115

>AT59934 WP_002461193.1 NZ_CP014022:2399960-2400130 [Staphylococcus lugdunensis]
MLTFNQNRSHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNHQSE

Download         Length: 171 bp

>AT59934 NZ_CP014022:2399960-2400130 [Staphylococcus lugdunensis]
ATGCTAACTTTTAATCAAAATCGTAGTCATAGTCTAGAACAGTCATTAAAAGAAGGGTATGCTCAGATGGCAGACCTTAA
TCTCTCCCTAGCAACAGAGGCTTTTCCAATTGAATGTGAAGCTTGTGATTGCAATGAAACTTATCTAACTTCCAATCATC
AGAGTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853V3R6

Antitoxin

Source ID Structure
AlphaFold DB A0A853V233

References