Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2388562..2389080 Replicon chromosome
Accession NZ_CP014022
Organism Staphylococcus lugdunensis strain FDAARGOS_141

Toxin (Protein)


Gene name TsdT Uniprot ID A0A853V532
Locus tag AL499_RS11180 Protein ID WP_002492077.1
Coordinates 2388868..2389080 (+) Length 71 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A853V130
Locus tag AL499_RS11175 Protein ID WP_002492098.1
Coordinates 2388562..2388855 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL499_RS11155 2384162..2384800 + 639 WP_002492090.1 thiamine phosphate synthase -
AL499_RS11160 2384890..2385765 + 876 WP_002461212.1 membrane protein insertase YidC -
AL499_RS11165 2386149..2386790 - 642 WP_002492092.1 HD domain-containing protein -
AL499_RS11170 2386912..2388396 - 1485 WP_062248904.1 cardiolipin synthase -
AL499_RS11175 2388562..2388855 + 294 WP_002492098.1 copper-sensing transcriptional repressor CsoR Antitoxin
AL499_RS11180 2388868..2389080 + 213 WP_002492077.1 heavy-metal-associated domain-containing protein Toxin
AL499_RS12585 2389171..2389308 + 138 WP_002461206.1 hypothetical protein -
AL499_RS11185 2389722..2390912 - 1191 WP_002461205.1 rod shape-determining protein RodA -
AL499_RS11190 2391268..2392338 + 1071 WP_002461204.1 D-alanine--D-alanine ligase -
AL499_RS11195 2392356..2393714 + 1359 WP_002492089.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(19-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-90)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 8087.02 Da        Isoelectric Point: 3.9947

>T59933 WP_002492077.1 NZ_CP014022:2388868-2389080 [Staphylococcus lugdunensis]
VEKRLIYITNVTNEDDLENLRTRLLEMIGVNEVVINFDERAVNVTFETSTNLNALEKEIYDAGYHAIDDL

Download         Length: 213 bp

>T59933 NZ_CP014022:2388868-2389080 [Staphylococcus lugdunensis]
GTGGAAAAGCGATTAATTTATATTACAAATGTGACTAATGAAGACGACTTGGAAAACTTACGAACAAGGTTATTAGAGAT
GATTGGTGTTAATGAAGTAGTGATCAATTTTGATGAACGTGCAGTTAATGTTACTTTCGAAACATCAACTAATTTAAATG
CACTTGAAAAAGAAATATATGATGCTGGCTATCATGCTATAGATGATTTATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11177.85 Da        Isoelectric Point: 6.6367

>AT59933 WP_002492098.1 NZ_CP014022:2388562-2388855 [Staphylococcus lugdunensis]
MNEQDHAHHSKIVKANLKSRLNRIEGQVRAINRMVEDDVYCDDVLTQIRATRSALTSVATKLLEHHMKSCIMDKINDGQE
VEAMEELLVTFQKMLKD

Download         Length: 294 bp

>AT59933 NZ_CP014022:2388562-2388855 [Staphylococcus lugdunensis]
TTGAACGAACAAGATCATGCACATCATTCTAAAATTGTAAAAGCAAATTTAAAATCTAGATTAAATCGTATAGAAGGACA
AGTGCGGGCAATTAATCGCATGGTTGAAGATGATGTTTATTGTGATGATGTGTTAACACAAATAAGAGCAACACGCTCAG
CATTAACGAGTGTAGCAACAAAACTATTAGAGCATCATATGAAAAGTTGTATCATGGATAAAATAAACGATGGGCAGGAA
GTTGAAGCGATGGAGGAATTGCTAGTTACATTTCAAAAGATGCTAAAAGACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853V532

Antitoxin

Source ID Structure
AlphaFold DB A0A853V130

References