Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1519313..1520949 Replicon chromosome
Accession NZ_CP014019
Organism Acinetobacter nosocomialis strain FDAARGOS_129

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag AL533_RS07395 Protein ID WP_104918848.1
Coordinates 1519313..1520644 (+) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag AL533_RS07400 Protein ID WP_001101310.1
Coordinates 1520641..1520949 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL533_RS07375 1515518..1516681 + 1164 WP_016805452.1 hypothetical protein -
AL533_RS07380 1516914..1517885 + 972 WP_104918845.1 5'/3'-nucleotidase SurE -
AL533_RS07385 1517897..1518535 + 639 WP_104918846.1 hypothetical protein -
AL533_RS07390 1518577..1519017 - 441 WP_104918847.1 HD domain-containing protein -
AL533_RS07395 1519313..1520644 + 1332 WP_104918848.1 type II toxin-antitoxin system HipA family toxin Toxin
AL533_RS07400 1520641..1520949 + 309 WP_001101310.1 helix-turn-helix domain-containing protein Antitoxin
AL533_RS07410 1521678..1522223 + 546 WP_104919249.1 TetR/AcrR family transcriptional regulator -
AL533_RS07415 1522357..1522950 + 594 WP_042077393.1 hypothetical protein -
AL533_RS19320 1522991..1523134 + 144 WP_155276878.1 hypothetical protein -
AL533_RS19330 1523327..1523494 + 168 WP_165395684.1 hypothetical protein -
AL533_RS07420 1523569..1524078 - 510 WP_042077395.1 YfbU family protein -
AL533_RS07430 1524317..1524835 + 519 WP_087606094.1 GNAT family N-acetyltransferase -
AL533_RS07435 1524912..1525862 + 951 WP_087606093.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(167-359)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-83)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 51089.13 Da        Isoelectric Point: 4.8460

>T59932 WP_104918848.1 NZ_CP014019:1519313-1520644 [Acinetobacter nosocomialis]
MKKLTIQALLNKNWIDIAELKLLEPKLGSGSASELEYELDYAIQYLDRRDEHACSLSLPVQILIKHESNTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPDSTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEKFDQPDQHYLVKFPRNKRSEIDCDILRAEYYYYQILNELGFNTIETTQM
QLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDIPQFICEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQGLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Download         Length: 1332 bp

>T59932 NZ_CP014019:1519313-1520644 [Acinetobacter nosocomialis]
ATGAAAAAATTAACAATACAAGCCTTACTAAACAAAAACTGGATAGATATAGCAGAGCTAAAACTGCTAGAACCTAAGTT
GGGTTCGGGTAGTGCCAGTGAACTAGAGTATGAATTGGATTATGCAATTCAATATTTAGACAGACGAGATGAGCACGCCT
GTAGTTTATCACTTCCTGTACAAATTCTTATCAAACATGAATCGAACACATGGTTTGGCTTTTTAGATGATATTGTTCCA
TCTGGCGCTGCACGCCGTTATTGGGTGAATTATCTAGATTTACAACGCTTAACCTATGCGGAACAAGAAAGTATTCTATT
AGAAAAAGGTGGAATGGCACCTGTTGGTAATTTACGAATTAAAGAAGCATTACCTCCACTAAACCCAGATTCAACCTTGC
ACTTACGTTATTTTTCTAAGGAAGATGTGGCTGAGCGTAATATTGATTTTCTGGAATATGCTCAACAAATGGGAGCTATT
AGTGGTGGTGCAACTGGTGCTGGTGGGGAAGCTCCCAAATTACTTATTCGTGTTTCACCGGAACAAAAAGTCTGGATTGA
CACCTACCAAGAAAAATTTGATCAGCCAGATCAGCATTATTTGGTGAAATTCCCGCGAAATAAACGTAGCGAGATTGATT
GCGATATTCTCAGAGCCGAATATTATTATTATCAGATACTCAATGAGTTAGGTTTCAACACAATTGAAACAACCCAAATG
CAGCTCATTGAAGGTACAAAATATCCGTCATTGTGGCTTCCAAGATTCGATACAGAATGGTGTGATCAATATTGGCACCG
CTATGGTCTAGAGTCTGTGTATTCTGTACTAAATAAGTCTTCTGGTAGCCATCTTAACCATTTCGAAGTAATTGAGGATC
TATGTAGATTACTCACAAGCATTGACTCAGATTTTGATATACCACAATTTATTTGTGAGTGGTTACAACGTGACTTACTT
AATATCATTTTTGGCAATTCAGATAACCACGGTCGTAATACATCGTTTATAAAAAAATCTGGAAAAATTTATCTTTCGCC
TATTTATGACTTTGCACCTATGAAAGCCGATCCAGAAGTTGTGACCAGATCGACGACTTGGGGAAGTCCGTATGAAGAAG
GAGGTGAATACCGGTGGGCGCAAATTACACAAAAACTTGCTCCTTGGTGCGATCCCGATTTATCTCTAGCAACATTAAGG
ACTTTGGCGAATAACCTGCTTGGCTTAAAGCAAGGATTAGTTGATAAAGGTGTACCAAAACAAATTATTGAAATGCCAGC
GCTGTCATTTGATTACATAGAAGCTAAATTGAAAAGATGGGAACTGCTATGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11630.54 Da        Isoelectric Point: 9.9701

>AT59932 WP_001101310.1 NZ_CP014019:1520641-1520949 [Acinetobacter nosocomialis]
MNVKNQTQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPNE

Download         Length: 309 bp

>AT59932 NZ_CP014019:1520641-1520949 [Acinetobacter nosocomialis]
ATGAATGTAAAAAATCAAACCCAAGACCGTCAGCAGATTCTTATAGATTTATATAAACAATATTTGTTGAGTGAGATTAC
TTTGGGGCAATTGCTATCGTATTTACGCAAAAATGTGTTGGGTTTGTCGCAAGAACAATATGCTAATTTGGTGGGTATAA
GCCGTCGGACTTTAACGGACATTGAGCAGGATAAAGGTAAACTCACTCAGTCTGTGTTAGATAAAGTGTTTAAGCCACTT
GGTTTAAAAGCAGGGCTTGTACCTACGCATGAACATATTGTTAGCAAAATTATAAAGCCAAACGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References