Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4233089..4233672 Replicon chromosome
Accession NZ_CP014018
Organism Pandoraea apista strain FDAARGOS_126

Toxin (Protein)


Gene name hicA Uniprot ID A0A9E9DDT9
Locus tag AL486_RS18800 Protein ID WP_010806546.1
Coordinates 4233089..4233280 (+) Length 64 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag AL486_RS18805 Protein ID WP_094068766.1
Coordinates 4233277..4233672 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL486_RS18780 4228778..4230064 - 1287 WP_104928100.1 terminase family protein -
AL486_RS18785 4230051..4230626 - 576 WP_104927692.1 hypothetical protein -
AL486_RS18790 4230683..4232059 - 1377 WP_104927693.1 chromosome partitioning protein ParB -
AL486_RS18795 4232142..4232867 + 726 WP_094068765.1 HNH endonuclease -
AL486_RS18800 4233089..4233280 + 192 WP_010806546.1 type II toxin-antitoxin system HicA family toxin Toxin
AL486_RS18805 4233277..4233672 + 396 WP_094068766.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
AL486_RS18810 4234204..4234830 - 627 WP_094068767.1 hypothetical protein -
AL486_RS18815 4234863..4235336 - 474 WP_104927694.1 RusA family crossover junction endodeoxyribonuclease -
AL486_RS18825 4235540..4236310 - 771 WP_104927696.1 hypothetical protein -
AL486_RS24140 4236267..4237277 - 1011 WP_172961502.1 DUF1376 domain-containing protein -
AL486_RS18835 4237274..4237705 - 432 WP_104927697.1 hypothetical protein -
AL486_RS18845 4238033..4238272 - 240 WP_172961503.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-124)


Sequences

Toxin        


Download         Length: 64 a.a.        Molecular weight: 7096.21 Da        Isoelectric Point: 11.3261

>T59930 WP_010806546.1 NZ_CP014018:4233089-4233280 [Pandoraea apista]
MTSADIIKRLKAAGFTEVSVRGSHHKFRHENGRVVIVPHPKKDMPIGTARSIFKQAGIDWRSE

Download         Length: 192 bp

>T59930 NZ_CP014018:4233089-4233280 [Pandoraea apista]
ATGACAAGCGCAGACATCATCAAACGACTGAAAGCCGCCGGATTCACCGAAGTGTCGGTGCGCGGCAGCCACCACAAGTT
TCGGCATGAGAACGGTCGAGTGGTGATCGTCCCGCACCCGAAAAAGGACATGCCGATTGGCACCGCCCGCTCGATCTTCA
AGCAAGCGGGCATTGACTGGAGAAGCGAATGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14637.52 Da        Isoelectric Point: 4.5604

>AT59930 WP_094068766.1 NZ_CP014018:4233277-4233672 [Pandoraea apista]
MKYPIYVWQEGDSAFGAAFPDLPGVHTAADTLDELERMAQEAVELMYEDSADAIPAPTYDIHKLHAHEVDDGTGCWMFVD
IDLSKVSSKAIRLNISLPERLVHQIDAVAEKRHMSRSAFLALAAQREMEHA

Download         Length: 396 bp

>AT59930 NZ_CP014018:4233277-4233672 [Pandoraea apista]
ATGAAATATCCGATCTACGTGTGGCAGGAAGGCGATAGCGCCTTCGGCGCCGCGTTCCCGGATCTTCCGGGGGTGCACAC
CGCTGCGGATACGCTCGACGAACTTGAGCGTATGGCGCAGGAAGCCGTCGAGCTTATGTACGAGGACAGCGCAGATGCGA
TCCCGGCCCCGACCTACGACATCCACAAGCTGCATGCGCACGAGGTGGATGACGGTACCGGCTGCTGGATGTTCGTCGAC
ATCGATCTGTCAAAGGTCAGCAGCAAGGCGATTCGACTGAACATCAGCCTGCCCGAGCGTCTCGTGCATCAAATCGATGC
AGTGGCTGAGAAGCGGCATATGTCGCGCTCGGCGTTTCTGGCTCTCGCGGCACAGCGCGAGATGGAACACGCCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References