Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1991997..1993848 Replicon chromosome
Accession NZ_CP014018
Organism Pandoraea apista strain FDAARGOS_126

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag AL486_RS09045 Protein ID WP_104927156.1
Coordinates 1991997..1992905 (+) Length 303 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag AL486_RS09050 Protein ID WP_082117814.1
Coordinates 1992907..1993848 (+) Length 314 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL486_RS09020 1987416..1988492 + 1077 WP_042118075.1 porin -
AL486_RS09025 1988798..1989667 + 870 WP_094068335.1 ABC transporter ATP-binding protein -
AL486_RS09030 1989706..1990488 + 783 WP_042114934.1 ABC transporter permease -
AL486_RS09035 1990504..1991298 + 795 WP_042114936.1 SDR family oxidoreductase -
AL486_RS09040 1991340..1991897 + 558 WP_042114937.1 cupin domain-containing protein -
AL486_RS09045 1991997..1992905 + 909 WP_104927156.1 alpha/beta fold hydrolase Toxin
AL486_RS09050 1992907..1993848 + 942 WP_082117814.1 IclR family transcriptional regulator Antitoxin
AL486_RS09055 1993845..1994651 + 807 WP_042114938.1 SDR family oxidoreductase -
AL486_RS09060 1994644..1996296 + 1653 WP_042114940.1 thiamine pyrophosphate-binding protein -
AL486_RS09065 1996289..1997107 + 819 WP_042114941.1 aspartate dehydrogenase -
AL486_RS09070 1997121..1998617 + 1497 WP_104927157.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(53-286)

Antitoxin

Transcription regulator IclR, C-terminal

(168-291)


Sequences

Toxin        


Download         Length: 303 a.a.        Molecular weight: 31405.53 Da        Isoelectric Point: 5.8839

>T59929 WP_104927156.1 NZ_CP014018:1991997-1992905 [Pandoraea apista]
MQAEASLSEVPEDAAVAPLRARLNAFPYRTLATRTGTVGYRCAGAHAEGGMPVVMLHGIGSGAASWLAQFEATGLNAELY
AWDAPGYGQTSNVADAEPHADAYADALEAWLDALGLKRVALVGHSLGAIMATKFASRSPQRVSGLFLCSPAGGYGKADPD
VRVSKRDSRLAMLDKLGPGGMARERSDNLVAPNAADLPRSWVKWNMARVHPAGYRQATHLLSNGDVAGELAQYVAANAGP
VAVAVGAQDAITTPAVCQTIADVAGVPLQIIEGAGHASYIETPDVLNVALAAWLERIAAGER

Download         Length: 909 bp

>T59929 NZ_CP014018:1991997-1992905 [Pandoraea apista]
ATGCAAGCCGAAGCCTCACTGTCCGAAGTGCCCGAAGATGCCGCCGTCGCACCGCTGCGCGCGCGTCTGAATGCTTTCCC
GTACCGCACGCTCGCCACGCGTACGGGCACCGTCGGCTATCGCTGCGCTGGCGCGCATGCCGAGGGTGGCATGCCGGTCG
TGATGCTGCACGGCATTGGGTCCGGCGCGGCGTCATGGCTGGCGCAGTTCGAAGCCACAGGGCTTAACGCCGAGCTTTAC
GCGTGGGACGCCCCGGGCTATGGGCAGACGTCGAACGTCGCCGATGCCGAGCCGCATGCCGATGCTTACGCCGACGCGCT
TGAGGCGTGGCTCGATGCCCTGGGGCTCAAGCGTGTCGCTCTCGTTGGCCACTCGCTGGGCGCGATCATGGCGACGAAGT
TTGCGAGCCGCTCCCCGCAGCGTGTGAGTGGACTCTTTCTCTGCTCGCCGGCCGGCGGTTACGGCAAGGCCGATCCGGAC
GTGCGCGTAAGCAAGCGCGATAGCCGTCTGGCGATGCTCGACAAGCTGGGCCCGGGCGGCATGGCCCGCGAGCGCAGCGA
CAATCTCGTCGCGCCGAATGCCGCAGACCTGCCGCGCTCCTGGGTGAAATGGAACATGGCGCGCGTGCATCCCGCCGGAT
ACCGGCAGGCGACGCACCTTCTCTCGAACGGCGACGTCGCCGGCGAGTTGGCGCAATACGTGGCCGCGAACGCCGGGCCG
GTGGCCGTGGCGGTCGGCGCACAGGATGCGATCACGACGCCCGCGGTTTGCCAGACGATTGCCGACGTGGCCGGCGTGCC
ACTGCAGATCATCGAAGGCGCGGGACACGCGTCGTACATCGAAACCCCGGACGTTCTGAACGTCGCGCTCGCGGCGTGGC
TCGAGCGCATCGCGGCAGGAGAGCGCTGA

Antitoxin


Download         Length: 314 a.a.        Molecular weight: 34121.88 Da        Isoelectric Point: 6.3621

>AT59929 WP_082117814.1 NZ_CP014018:1992907-1993848 [Pandoraea apista]
MAPATPKRAAAAPDAQIEDDKLGLQDTQTDGDELAEGSTSDTRYLVPGLERGLRILTQFSPREAVFSAPELSQRLGIPRT
TVFRLLQTLEAMGFLERAGSEKNFRLGVAVLRLGFEYLSSLELTDLGIPIIERLRDATQLTSHIVIRDGRDIVFVAKAQS
VAGVFNSIKVNVGTRLPAHATVHGHVLMGDLTLAELRALYPEKTLEKYTPQTPETLAELFERVREDAERGYAVSASSFER
GISVVSAPVRNDAGRICAAITVTIPRANIDSSMLDAGLIGQVREAADALSHRLNYRPGSDRQPTPYMKSLGLK

Download         Length: 942 bp

>AT59929 NZ_CP014018:1992907-1993848 [Pandoraea apista]
ATGGCACCGGCAACCCCGAAGCGCGCAGCGGCAGCGCCCGACGCGCAGATCGAAGACGACAAGCTCGGTCTTCAGGACAC
CCAGACCGATGGCGACGAACTCGCCGAAGGTTCAACGTCCGACACTCGTTATCTCGTGCCAGGTCTGGAGCGCGGCTTGC
GCATTCTTACGCAGTTCTCGCCGCGCGAGGCCGTATTCAGCGCGCCGGAGTTGTCGCAACGCCTCGGCATTCCGCGTACC
ACCGTTTTCCGTTTGTTGCAGACGCTTGAAGCGATGGGTTTTCTGGAGCGCGCGGGGAGCGAGAAGAATTTCCGTCTGGG
CGTGGCAGTGCTGCGTCTGGGCTTCGAATACCTCAGTTCGCTGGAGTTGACCGATCTGGGGATTCCGATCATCGAACGGC
TGCGCGACGCCACGCAATTGACCTCGCACATCGTGATCCGGGACGGGCGAGACATCGTGTTCGTGGCGAAGGCGCAAAGC
GTTGCCGGCGTTTTCAATTCGATCAAGGTAAACGTCGGCACGCGTCTGCCGGCGCATGCAACGGTGCATGGCCATGTGCT
GATGGGCGACCTGACGCTGGCCGAGCTTCGCGCGCTGTATCCGGAAAAGACGCTGGAAAAATACACACCGCAAACGCCCG
AGACGCTTGCGGAGTTGTTCGAACGGGTGCGTGAAGACGCCGAGCGCGGTTACGCGGTGTCGGCTTCGTCGTTCGAGCGG
GGCATCAGTGTCGTGAGTGCACCGGTGCGCAACGACGCGGGCCGTATCTGCGCCGCCATCACCGTGACCATTCCGCGCGC
CAACATCGATTCGTCAATGCTCGATGCGGGGCTGATCGGACAGGTGCGCGAGGCGGCCGATGCGCTGTCGCATCGTCTGA
ACTATCGCCCGGGCAGCGACCGTCAACCCACCCCCTACATGAAGTCACTGGGATTGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References