Detailed information of TA system TA059928

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 4720928..4721553
• Replicon: chromosome
• Accession: NZ_CP014017
• Organism: Serratia liquefaciens strain FDAARGOS_125

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A515CU05
• Locus tag: AL485_RS22540
• Protein ID: WP_048760244.1
• Coordinates: 4721371..4721553 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: AL485_RS22535
• Protein ID: WP_048760245.1
• Coordinates: 4720928..4721341 (-)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AL485_RS22505	4716152..4716874	+	723	WP_020827491.1	RNA polymerase sigma factor FliA	-
AL485_RS22510	4716933..4717442	+	510	WP_041414695.1	flagella biosynthesis regulatory protein FliZ	-
AL485_RS22515	4717570..4718562	+	993	WP_048760246.1	D-cysteine desulfhydrase	-
AL485_RS22520	4718677..4719477	+	801	WP_046373262.1	cystine ABC transporter substrate-binding protein	-
AL485_RS22525	4719477..4720139	+	663	WP_020827487.1	cystine ABC transporter permease	-
AL485_RS22530	4720143..4720895	+	753	WP_046373263.1	L-cystine ABC transporter ATP-binding protein YecC	-
AL485_RS22535	4720928..4721341	-	414	WP_048760245.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
AL485_RS22540	4721371..4721553	-	183	WP_048760244.1	type II toxin-antitoxin system HicA family toxin	Toxin
AL485_RS22545	4721720..4725691	-	3972	WP_061069101.1	trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	fliA / fliZ	4716152..4731291	15139

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6768.95 Da
• Isoelectric Point: 10.7801

>T59928 WP_048760244.1 NZ_CP014017:c4721553-4721371 [Serratia liquefaciens]
VKSSELIGLLEQEGWVLTRIKGSHHQFKHPNSRLVITVPHPRKDLKAGTLRQIMKDAGLC

Nucleotide

• Length: 183 bp

>T59928 NZ_CP014017:c4721553-4721371 [Serratia liquefaciens]
GTGAAAAGTTCAGAACTGATCGGGCTGTTAGAACAGGAAGGTTGGGTTTTAACGCGGATCAAGGGAAGCCACCATCAGTT
TAAGCACCCGAACTCCCGTCTGGTGATCACCGTTCCACATCCGCGAAAGGATCTGAAAGCGGGGACGCTGCGCCAAATCA
TGAAAGATGCCGGATTGTGCTAA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15093.75 Da
• Isoelectric Point: 4.8403

>AT59928 WP_048760245.1 NZ_CP014017:c4721341-4720928 [Serratia liquefaciens]
MFYPAYVHSEPDGSASGFFPDVPGCYFAGDTLDRAFEDARSALDAHFEFLSEDNQPIPGPQAVTFHLAQNNDSLNGGQWL
LVNINMDKFDGRAERINITLPHRLLNRIDSLVQQHPGYGSRSAFLAAAARNELLKAG

Nucleotide

• Length: 414 bp

>AT59928 NZ_CP014017:c4721341-4720928 [Serratia liquefaciens]
ATGTTCTACCCTGCTTATGTACATTCTGAACCGGACGGCAGCGCCAGCGGCTTCTTTCCCGATGTGCCAGGCTGCTATTT
TGCCGGCGATACCCTGGACAGAGCCTTTGAAGACGCCAGAAGTGCGCTGGACGCCCATTTCGAATTCTTGAGCGAAGACA
ATCAGCCCATTCCCGGCCCACAAGCCGTGACCTTTCATCTGGCACAGAATAACGACAGTCTGAATGGCGGGCAGTGGTTG
TTGGTCAATATTAATATGGATAAGTTTGATGGTCGGGCGGAGCGTATCAATATTACCTTGCCGCACCGCCTGCTGAACCG
CATAGATTCTCTGGTGCAGCAGCATCCCGGTTACGGTAGCCGCAGCGCCTTTTTGGCCGCCGCCGCCCGCAATGAATTAT
TGAAAGCCGGGTAG

Structures

Toxin

• AlphaFold DB: A0A515CU05