Detailed information of TA system TA059923

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 3399155..3399703
• Replicon: chromosome
• Accession: NZ_CP014017
• Organism: Serratia liquefaciens strain FDAARGOS_125

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: AL485_RS16145
• Protein ID: WP_071888888.1
• Coordinates: 3399155..3399430 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: AL485_RS16150
• Protein ID: WP_172958983.1
• Coordinates: 3399431..3399703 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AL485_RS16125	3394585..3395880	-	1296	WP_048759766.1	cytosine permease	-
AL485_RS16130	3395901..3396590	-	690	WP_020828619.1	PAS and helix-turn-helix domain-containing protein	-
AL485_RS16135	3396616..3397026	-	411	WP_020828618.1	GNAT family N-acetyltransferase	-
AL485_RS16140	3397371..3398291	-	921	WP_048759763.1	alpha/beta hydrolase	-
AL485_RS16145	3399155..3399430	-	276	WP_071888888.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AL485_RS16150	3399431..3399703	-	273	WP_172958983.1	ribbon-helix-helix domain-containing protein	Antitoxin
AL485_RS16155	3399787..3400632	-	846	WP_061068977.1	DUF4942 domain-containing protein	-
AL485_RS16160	3400739..3401068	-	330	Protein_3100	hypothetical protein	-
AL485_RS16165	3401065..3401433	-	369	WP_071888889.1	TA system toxin CbtA family protein	-
AL485_RS16170	3401488..3401829	-	342	WP_061068979.1	type IV toxin-antitoxin system YeeU family antitoxin	-
AL485_RS16175	3401840..3402319	-	480	WP_061069170.1	DNA repair protein RadC	-
AL485_RS16180	3402356..3402823	-	468	WP_172958984.1	antirestriction protein	-
AL485_RS16185	3402976..3404211	-	1236	WP_061068981.1	O-antigen ligase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3399155..3413522	14367

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (6-42)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10467.97 Da
• Isoelectric Point: 7.4671

>T59923 WP_071888888.1 NZ_CP014017:c3399430-3399155 [Serratia liquefaciens]
MQVVWTNYALQDLDRLHEFLASANAIAAAHVIQSLVAAPVNLLTHSRIGSVLERYEPREVRRLIVGSYEMHYEINASSLS
ILRVWHTRENR

Nucleotide

• Length: 276 bp

>T59923 NZ_CP014017:c3399430-3399155 [Serratia liquefaciens]
ATGCAGGTGGTCTGGACCAACTATGCGCTTCAAGATTTAGATAGACTACACGAGTTTCTTGCAAGCGCGAATGCTATCGC
TGCTGCGCATGTCATTCAATCTCTTGTTGCTGCCCCGGTCAATTTACTGACTCACTCCCGTATAGGCTCAGTACTGGAAA
GATATGAGCCACGAGAAGTTCGCCGGTTGATTGTTGGCAGCTATGAAATGCACTACGAAATTAACGCCAGTTCGCTCTCT
ATTCTACGGGTATGGCATACACGAGAAAATAGATAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10151.56 Da
• Isoelectric Point: 6.4877

>AT59923 WP_172958983.1 NZ_CP014017:c3399703-3399431 [Serratia liquefaciens]
VHTRVITAHIPVEMAEKIDELAANYDRSRGWIVKQALAAIIEQEENHHQMILQGLADVDAKRVIEHSDVLKWANSLSSEK
PLPLPQSGHR

Nucleotide

• Length: 273 bp

>AT59923 NZ_CP014017:c3399703-3399431 [Serratia liquefaciens]
GTGCACACTAGAGTCATCACAGCTCACATACCGGTTGAAATGGCTGAAAAAATCGATGAACTGGCAGCAAACTATGATCG
CTCGCGGGGCTGGATAGTCAAACAAGCTTTGGCTGCTATCATTGAACAAGAAGAAAATCACCATCAGATGATTTTGCAGG
GACTGGCGGATGTCGATGCAAAGCGGGTCATCGAGCATTCTGATGTTCTTAAATGGGCAAACAGTTTGAGCAGCGAAAAA
CCGCTTCCTTTACCTCAATCAGGGCACCGATAA