Detailed information of TA system TA059922

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelE-RHH
• Location: 2983337..2983902
• Replicon: chromosome
• Accession: NZ_CP014017
• Organism: Serratia liquefaciens strain FDAARGOS_125

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: AL485_RS14205
• Protein ID: WP_048760522.1
• Coordinates: 2983337..2983615 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A380ARC2
• Locus tag: AL485_RS14210
• Protein ID: WP_020837302.1
• Coordinates: 2983633..2983902 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AL485_RS14185	2979499..2979837	-	339	WP_041415733.1	PTS lactose/cellobiose transporter subunit IIA	-
AL485_RS14190	2980195..2980764	+	570	WP_020837308.1	peptidylprolyl isomerase A	-
AL485_RS14195	2980926..2982611	+	1686	WP_046372487.1	sensor histidine kinase	-
AL485_RS14200	2982611..2983336	+	726	WP_020837306.1	two-component system response regulator BtsR	-
AL485_RS14205	2983337..2983615	-	279	WP_048760522.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AL485_RS14210	2983633..2983902	-	270	WP_020837302.1	hypothetical protein	Antitoxin
AL485_RS14215	2984128..2985654	+	1527	WP_048760525.1	DUF853 family protein	-
AL485_RS14220	2985765..2986340	+	576	WP_048760527.1	aminodeoxychorismate synthase component II	-
AL485_RS14225	2986472..2987689	+	1218	WP_048760529.1	aspartate aminotransferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-89)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10300.95 Da
• Isoelectric Point: 9.4608

>T59922 WP_048760522.1 NZ_CP014017:c2983615-2983337 [Serratia liquefaciens]
VKLKWTDPAIADRMAIYDYLASKNPIAAAEIDALISAAASQLSRNPSSGKVGRVSGTLEWVIHHFYLLIYEVKNDLLIIL
AVVHSRRQWPKD

Nucleotide

• Length: 279 bp

>T59922 NZ_CP014017:c2983615-2983337 [Serratia liquefaciens]
GTGAAGCTAAAGTGGACGGATCCCGCAATTGCTGACCGTATGGCAATTTATGACTATCTTGCGTCAAAGAACCCGATAGC
TGCCGCAGAGATTGATGCTTTGATTTCTGCGGCGGCAAGCCAACTATCCCGAAACCCATCAAGTGGCAAAGTGGGCCGGG
TTTCAGGTACACTTGAATGGGTCATTCATCATTTTTACCTACTGATTTATGAAGTAAAAAATGACCTTCTTATTATTTTG
GCAGTCGTACATTCCCGCCGGCAATGGCCAAAGGATTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10373.64 Da
• Isoelectric Point: 5.2281

>AT59922 WP_020837302.1 NZ_CP014017:c2983902-2983633 [Serratia liquefaciens]
MSESTVVIRVDDELKIAFASAAKAADRTASQLLRDFMRDFVSRQSQQKEYEQWLQEKVDLSRKALQEGRVVDNEDVEAYF
AERRAKSMR

Nucleotide

• Length: 270 bp

>AT59922 NZ_CP014017:c2983902-2983633 [Serratia liquefaciens]
ATGTCTGAATCTACCGTGGTTATCCGCGTGGATGACGAGTTAAAAATAGCTTTTGCCAGCGCGGCCAAAGCAGCGGATCG
AACGGCATCTCAGCTTTTACGCGATTTCATGCGAGATTTTGTCAGTCGACAATCGCAGCAAAAAGAGTATGAACAGTGGT
TGCAGGAGAAGGTCGATTTAAGCCGAAAAGCGCTCCAGGAAGGAAGAGTGGTTGATAACGAGGACGTTGAGGCTTATTTC
GCCGAGCGCAGGGCAAAATCAATGCGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A380ARC2