Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1494933..1495560 Replicon chromosome
Accession NZ_CP014017
Organism Serratia liquefaciens strain FDAARGOS_125

Toxin (Protein)


Gene name Hha Uniprot ID A0A379ZYL4
Locus tag AL485_RS07260 Protein ID WP_020825514.1
Coordinates 1495357..1495560 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A379ZYL8
Locus tag AL485_RS07255 Protein ID WP_020825515.1
Coordinates 1494933..1495301 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL485_RS07225 1490981..1491235 + 255 WP_048759566.1 type B 50S ribosomal protein L31 -
AL485_RS07230 1491248..1491388 + 141 WP_012005563.1 type B 50S ribosomal protein L36 -
AL485_RS07235 1491501..1492379 - 879 WP_020825520.1 metal ABC transporter substrate-binding protein -
AL485_RS07240 1492405..1493262 - 858 WP_048759567.1 metal ABC transporter permease -
AL485_RS07245 1493249..1493971 - 723 WP_048759568.1 ABC transporter ATP-binding protein -
AL485_RS25360 1493968..1494114 - 147 WP_020825517.1 hypothetical protein -
AL485_RS07250 1494444..1494770 + 327 WP_048759754.1 hypothetical protein -
AL485_RS07255 1494933..1495301 + 369 WP_020825515.1 Hha toxicity modulator TomB Antitoxin
AL485_RS07260 1495357..1495560 + 204 WP_020825514.1 hemolysin expression modulator Hha Toxin
AL485_RS07265 1495637..1496569 - 933 WP_020825513.1 LysR family transcriptional regulator -
AL485_RS07270 1496708..1498495 + 1788 WP_048759571.1 adenine deaminase -
AL485_RS07275 1498659..1500002 + 1344 WP_020825511.1 NCS2 family permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1494417..1504611 10194


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8075.37 Da        Isoelectric Point: 6.9764

>T59919 WP_020825514.1 NZ_CP014017:1495357-1495560 [Serratia liquefaciens]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTAVWKFVR

Download         Length: 204 bp

>T59919 NZ_CP014017:1495357-1495560 [Serratia liquefaciens]
ATGACTAAAACTGATTATCTGATGCGTTTACGTAAATGCACCACTATTGACACCCTTGAACGCGTTATTGAAAAAAATAA
GTATGAGCTTTCGGATGACGAATTGGAGCTGTTTTACTCTGCAGCTGACCACCGTCTGGCTGAGCTCACCATGAATAAGC
TCTACGATAAAATCCCAACGGCCGTTTGGAAGTTCGTACGTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14189.89 Da        Isoelectric Point: 4.5140

>AT59919 WP_020825515.1 NZ_CP014017:1494933-1495301 [Serratia liquefaciens]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEGICTTMKS

Download         Length: 369 bp

>AT59919 NZ_CP014017:1494933-1495301 [Serratia liquefaciens]
ATGGATGAGTATTCGCCTAAAAGGCACGATATTGCTCAGCTGAAATTCTTGTGCGAAAATTTGTATGATGAAGGCATAGC
CACGCTGGGCGACAGCCACCACGGCTGGGTGAACGACCCAACGTCTTCCGTCAACCTCCAGCTTAATGAGTTGATTGAAC
ATATTGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAAAGTGATTTATCGGAGTTAGTCGAGGAATATCTC
GATGATACCTACACGCTGTTCAGCAGTTACGGTATCAATGATTCCGATCTGCGTCGCTGGCAAAAAACCAAGGCGCGATT
ATTCAGAATGTTCTCAGGAGAGGGCATCTGTACGACAATGAAATCTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A379ZYL4

Antitoxin

Source ID Structure
AlphaFold DB A0A379ZYL8

References