Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 379783..380297 Replicon chromosome
Accession NZ_CP014016
Organism Staphylococcus simulans strain FDAARGOS_124

Toxin (Protein)


Gene name TsdT Uniprot ID A0A133QQ97
Locus tag AL483_RS14650 Protein ID WP_002481764.1
Coordinates 380091..380297 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A133QQA1
Locus tag AL483_RS14645 Protein ID WP_002481765.1
Coordinates 379783..380076 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL483_RS14620 375178..375816 + 639 WP_002481770.1 thiamine phosphate synthase -
AL483_RS14625 375905..376774 + 870 WP_002481769.1 membrane protein insertase YidC -
AL483_RS14630 376900..377412 + 513 WP_002481768.1 GNAT family N-acetyltransferase -
AL483_RS14635 377469..378119 - 651 WP_061054647.1 HD domain-containing protein -
AL483_RS14640 378143..379624 - 1482 WP_002481766.1 cardiolipin synthase -
AL483_RS14645 379783..380076 + 294 WP_002481765.1 copper-sensing transcriptional repressor CsoR Antitoxin
AL483_RS14650 380091..380297 + 207 WP_002481764.1 heavy-metal-associated domain-containing protein Toxin
AL483_RS14655 380316..380522 + 207 WP_002481763.1 copper ion binding protein -
AL483_RS14660 380615..382807 + 2193 WP_061054648.1 heavy metal translocating P-type ATPase -
AL483_RS25420 382889..383029 + 141 WP_023016106.1 hypothetical protein -
AL483_RS14665 383133..384449 - 1317 WP_061054649.1 ISL3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(24-65)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7861.82 Da        Isoelectric Point: 4.2670

>T59908 WP_002481764.1 NZ_CP014016:380091-380297 [Staphylococcus simulans]
MHSSVIQISGMETEEQQHILQEHLQQMIGMSEVQVDLKSQEVKASYQTPISLNNLEKEIYDQGYQILN

Download         Length: 207 bp

>T59908 NZ_CP014016:380091-380297 [Staphylococcus simulans]
ATGCATAGTAGTGTGATTCAAATCAGTGGTATGGAAACTGAAGAACAACAGCATATTTTGCAAGAACATTTGCAGCAAAT
GATTGGTATGTCAGAAGTGCAAGTGGATCTGAAATCACAAGAAGTGAAAGCGAGTTACCAGACACCAATCAGTTTAAACA
ATTTGGAAAAAGAAATTTATGATCAAGGTTACCAAATATTAAATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11033.69 Da        Isoelectric Point: 6.9688

>AT59908 WP_002481765.1 NZ_CP014016:379783-380076 [Staphylococcus simulans]
MTQEERAHHSEKIKSNLKARLNRIEGQVRAINRMIDEDVYCDDVLTQIRATRSALNSVAVKLLDHHMKGCILHKAEDGQA
EAAMEELLVTVQKLIKD

Download         Length: 294 bp

>AT59908 NZ_CP014016:379783-380076 [Staphylococcus simulans]
ATGACGCAAGAAGAACGCGCACATCATTCAGAAAAAATAAAATCTAACCTTAAAGCACGACTGAATCGTATAGAAGGACA
AGTCAGAGCGATTAATCGCATGATAGATGAAGATGTTTATTGTGATGATGTTTTAACACAAATCAGAGCGACACGTTCAG
CTTTGAATAGTGTTGCTGTAAAATTGCTGGATCATCATATGAAAGGCTGTATTTTGCATAAAGCTGAAGATGGACAAGCA
GAAGCTGCAATGGAAGAATTATTAGTTACCGTCCAAAAATTAATTAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A133QQ97

Antitoxin

Source ID Structure
AlphaFold DB A0A133QQA1

References