Detailed information of TA system TA059898

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 3785449..3786268
• Replicon: chromosome
• Accession: NZ_CP014015
• Organism: Citrobacter amalonaticus strain FDAARGOS_122

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: A0A2K9PA99
• Locus tag: AL479_RS18195
• Protein ID: WP_061077081.1
• Coordinates: 3785449..3785706 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: AL479_RS18200
• Protein ID: WP_061077082.1
• Coordinates: 3785717..3786268 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AL479_RS18165	3780540..3781733	+	1194	WP_102602111.1	tryptophan synthase subunit beta	-
AL479_RS18170	3781733..3782536	+	804	WP_061077077.1	tryptophan synthase subunit alpha	-
AL479_RS18175	3782583..3783863	-	1281	WP_192575236.1	aspartyl protease family protein	-
AL479_RS18180	3784196..3784420	-	225	WP_061077079.1	helix-turn-helix transcriptional regulator	-
AL479_RS18185	3784434..3784997	-	564	WP_061077080.1	DUF2975 domain-containing protein	-
AL479_RS18195	3785449..3785706	+	258	WP_061077081.1	YjhX family toxin	Toxin
AL479_RS18200	3785717..3786268	+	552	WP_061077082.1	N-acetyltransferase	Antitoxin
AL479_RS18205	3786320..3787066	+	747	WP_061077083.1	class I SAM-dependent methyltransferase	-
AL479_RS18210	3787744..3788328	+	585	WP_061077084.1	hypothetical protein	-
AL479_RS18215	3788388..3789248	-	861	WP_061077085.1	ketose-bisphosphate aldolase	-
AL479_RS18220	3789251..3790657	-	1407	WP_061077086.1	fructose-specific PTS transporter subunit EIIC	-
AL479_RS18225	3790679..3791152	-	474	WP_061077087.1	PTS sugar transporter subunit IIA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9550.05 Da
• Isoelectric Point: 11.1381

>T59898 WP_061077081.1 NZ_CP014015:3785449-3785706 [Citrobacter amalonaticus]
MNLSRQEQRTLHVLAKGGRITHVRDASGRVTAVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QPDNR

Nucleotide

• Length: 258 bp

>T59898 NZ_CP014015:3785449-3785706 [Citrobacter amalonaticus]
ATGAATTTATCCCGTCAGGAACAACGTACCTTACACGTTCTCGCCAAAGGTGGACGTATTACGCACGTCCGCGATGCGTC
AGGCCGCGTCACTGCCGTTGAATGCTACAGCCGCGAAGGGCTGCTGCTCACCGACTGTACACTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAGCTGATCAAATCCGTTAATGGTCAGCCGTACCGCATTAATACCACCGGGCTGAACAACGTTCGTGCT
CAGCCAGATAACCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20302.28 Da
• Isoelectric Point: 6.5740

>AT59898 WP_061077082.1 NZ_CP014015:3785717-3786268 [Citrobacter amalonaticus]
MTTRNFTFHITDESDANDIREVETRAFGYSKEACLVASLLEDDTARPTLSLLARQAGTAVGHILFTRATFKGEMHSPLMH
ILAPLAVIPEYQGKGVGGLLIRTGLEHLRSMGCQCVFVLGHATYYPRHGFEPCAGDKGYPAPYPIAEEHKACWMMQSLSA
QPLDRVGDIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT59898 NZ_CP014015:3785717-3786268 [Citrobacter amalonaticus]
ATGACAACACGCAACTTCACTTTTCATATCACCGATGAAAGTGATGCCAACGACATCCGGGAAGTCGAAACCCGCGCCTT
TGGCTACAGTAAAGAGGCCTGCCTGGTGGCTTCTTTGCTCGAGGACGACACCGCGCGCCCAACGCTATCGTTGCTGGCCA
GACAGGCAGGTACAGCCGTCGGGCATATCCTGTTTACCCGGGCGACCTTCAAAGGAGAAATGCATTCGCCGCTGATGCAT
ATCCTGGCTCCTCTGGCGGTCATACCTGAATACCAGGGGAAGGGCGTGGGCGGATTATTGATTCGTACCGGTTTAGAACA
CTTACGGTCGATGGGATGTCAGTGCGTTTTTGTTCTCGGCCATGCCACTTACTATCCGCGACATGGATTCGAACCCTGCG
CAGGAGACAAAGGCTATCCCGCACCTTACCCCATTGCGGAGGAACATAAGGCCTGCTGGATGATGCAGTCCCTCTCTGCA
CAACCCCTTGATCGTGTCGGCGACATTCAATGTGCGCAGGCCTTAATGAAACCGGAGCACTGGCGTGAATAG

Structures

Toxin

• AlphaFold DB: A0A2K9PA99