Detailed information of TA system TA059895

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 2963196..2964016
• Replicon: chromosome
• Accession: NZ_CP014015
• Organism: Citrobacter amalonaticus strain FDAARGOS_122

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: -
• Locus tag: AL479_RS14305
• Protein ID: WP_061076535.1
• Coordinates: 2963759..2964016 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: AL479_RS14300
• Protein ID: WP_061076534.1
• Coordinates: 2963196..2963747 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AL479_RS14270	2958841..2960130	+	1290	WP_061076529.1	arsenite efflux transporter membrane subunit ArsB	-
AL479_RS14275	2960143..2960568	+	426	WP_061076530.1	glutaredoxin-dependent arsenate reductase	-
AL479_RS14280	2960599..2961237	-	639	Protein_2680	arsenical pump-driving ATPase	-
AL479_RS14285	2961579..2961971	-	393	WP_061076531.1	VOC family protein	-
AL479_RS14290	2962019..2962270	-	252	WP_061076532.1	hypothetical protein	-
AL479_RS14295	2962398..2963144	-	747	WP_061076533.1	methyltransferase domain-containing protein	-
AL479_RS14300	2963196..2963747	-	552	WP_061076534.1	N-acetyltransferase	Antitoxin
AL479_RS14305	2963759..2964016	-	258	WP_061076535.1	YjhX family toxin	Toxin
AL479_RS14315	2964393..2964833	-	441	WP_071887632.1	GNAT family N-acetyltransferase	-
AL479_RS14320	2964978..2965370	-	393	WP_000493336.1	VOC family protein	-
AL479_RS14325	2965940..2966548	+	609	WP_061076536.1	DUF1062 domain-containing protein	-
AL479_RS14330	2966686..2967030	+	345	WP_061076537.1	hypothetical protein	-
AL479_RS14335	2967064..2968602	-	1539	WP_042922208.1	IS66 family transposase	-
AL479_RS14340	2968652..2968998	-	347	Protein_2691	IS66 family insertion sequence element accessory protein TnpB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2952233..2994212	41979

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (19-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9582.10 Da
• Isoelectric Point: 11.1381

>T59895 WP_061076535.1 NZ_CP014015:c2964016-2963759 [Citrobacter amalonaticus]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYTREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T59895 NZ_CP014015:c2964016-2963759 [Citrobacter amalonaticus]
ATGAATTTATCCCGTCAGGAACAACGTACGTTACACGTTCTCGCTAAAGGTGGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACACCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGTCAGCCCTATCGAATCAACACTACCGGGCTGAATAACGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20401.41 Da
• Isoelectric Point: 6.7154

>AT59895 WP_061076534.1 NZ_CP014015:c2963747-2963196 [Citrobacter amalonaticus]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGRRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPGEHKACWMMQSLTA
QPMNVTGHIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT59895 NZ_CP014015:c2963747-2963196 [Citrobacter amalonaticus]
ATGACAGCACACCACTTCACTTTTCAAATCACAGATGAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAACGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCTGCGTTATCGCTGCTGGCCC
GACATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGGGAAATGGATTCACCGCTGATGCAT
ATCCTCGCTCCCCTGGCAGTCATACCGGAATACCAGGGGATGGGCGTGGGACGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACAGTATTTGTGCTCGGCCACGCCACCTATTACCCCAGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGGGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGAACGTGACCGGCCACATCCAGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA