Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1678987..1679615 Replicon chromosome
Accession NZ_CP014015
Organism Citrobacter amalonaticus strain FDAARGOS_122

Toxin (Protein)


Gene name vapC Uniprot ID A0A8I0T143
Locus tag AL479_RS08050 Protein ID WP_061075712.1
Coordinates 1678987..1679373 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag AL479_RS08055 Protein ID WP_161215612.1
Coordinates 1679373..1679615 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL479_RS08030 1674340..1675677 + 1338 WP_061075708.1 VWA domain-containing protein -
AL479_RS08035 1675695..1677191 + 1497 WP_061075709.1 HAMP domain-containing histidine kinase -
AL479_RS08040 1677196..1677882 + 687 WP_061075710.1 response regulator transcription factor -
AL479_RS08045 1678027..1678956 + 930 WP_061075711.1 formate dehydrogenase accessory protein FdhE -
AL479_RS08050 1678987..1679373 - 387 WP_061075712.1 type II toxin-antitoxin system VapC family toxin Toxin
AL479_RS08055 1679373..1679615 - 243 WP_161215612.1 ribbon-helix-helix domain-containing protein Antitoxin
AL479_RS08060 1679823..1680755 + 933 WP_061075713.1 alpha/beta hydrolase -
AL479_RS08065 1680770..1681711 - 942 WP_042325456.1 fatty acid biosynthesis protein FabY -
AL479_RS08070 1681756..1682193 - 438 WP_061075714.1 D-tyrosyl-tRNA(Tyr) deacylase -
AL479_RS08075 1682190..1683062 - 873 WP_044257165.1 virulence factor BrkB family protein -
AL479_RS08080 1683056..1683655 - 600 WP_061075715.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14442.74 Da        Isoelectric Point: 9.4120

>T59894 WP_061075712.1 NZ_CP014015:c1679373-1678987 [Citrobacter amalonaticus]
MQKGPVLFDTNILIDLFSGHQEAQRVLEAYPPQNAISLITWMEVMVGAKKYHQEYRTRVALSAFNIIGVSLEIAERSVNL
RQEYGMKLPDAIILATAQIHRFALVTRNTRDFAGIPGVITPYQLQTGR

Download         Length: 387 bp

>T59894 NZ_CP014015:c1679373-1678987 [Citrobacter amalonaticus]
ATGCAAAAGGGACCCGTGTTGTTCGATACCAATATCCTGATTGATTTATTTAGCGGGCACCAGGAAGCGCAGCGGGTACT
GGAAGCGTATCCGCCGCAGAATGCCATCAGCTTGATTACCTGGATGGAAGTCATGGTGGGGGCAAAAAAATACCATCAGG
AATATCGTACGCGTGTGGCATTGAGTGCGTTCAATATCATCGGTGTATCACTGGAAATTGCTGAGCGAAGCGTGAATCTC
AGGCAGGAATATGGGATGAAACTTCCGGACGCGATCATTCTGGCTACAGCGCAGATTCATCGGTTTGCGCTTGTGACGCG
CAACACCAGAGATTTTGCAGGGATCCCTGGCGTCATTACCCCTTATCAGTTGCAAACCGGACGATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9335.53 Da        Isoelectric Point: 4.2075

>AT59894 WP_161215612.1 NZ_CP014015:c1679615-1679373 [Citrobacter amalonaticus]
IMAGMDMGRILLDLSDEVIKRLDDLKQQRNLPRAELLREAVEQYLERQGQAETTISNALGLWQGCEEDGVEYQRTLREEW

Download         Length: 243 bp

>AT59894 NZ_CP014015:c1679615-1679373 [Citrobacter amalonaticus]
ATAATGGCTGGGATGGACATGGGCAGAATATTACTCGACTTATCCGATGAGGTGATCAAACGCCTTGATGATCTCAAGCA
GCAGCGGAATCTGCCCCGTGCGGAGTTGCTGCGCGAAGCGGTTGAACAGTACCTTGAAAGGCAAGGCCAGGCTGAAACCA
CAATTTCCAATGCGCTGGGGCTCTGGCAGGGTTGTGAGGAAGACGGCGTTGAGTATCAGAGGACGCTGCGCGAGGAATGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References