Detailed information of TA system TA059892

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 1031061..1031715
• Replicon: chromosome
• Accession: NZ_CP014015
• Organism: Citrobacter amalonaticus strain FDAARGOS_122

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: AL479_RS04925
• Protein ID: WP_061075274.1
• Coordinates: 1031061..1031468 (-)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A0F6TWP9
• Locus tag: AL479_RS04930
• Protein ID: WP_042322123.1
• Coordinates: 1031449..1031715 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AL479_RS04905	1026966..1028699	-	1734	WP_061075271.1	single-stranded-DNA-specific exonuclease RecJ	-
AL479_RS04910	1028705..1029418	-	714	WP_061075272.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
AL479_RS04915	1029442..1030338	-	897	WP_042999367.1	site-specific tyrosine recombinase XerD	-
AL479_RS04920	1030439..1030960	+	522	WP_061075273.1	flavodoxin FldB	-
AL479_RS04925	1031061..1031468	-	408	WP_061075274.1	protein YgfX	Toxin
AL479_RS04930	1031449..1031715	-	267	WP_042322123.1	FAD assembly factor SdhE	Antitoxin
AL479_RS04935	1031972..1032952	+	981	WP_061075275.1	tRNA-modifying protein YgfZ	-
AL479_RS04940	1033034..1033693	-	660	WP_061075276.1	hemolysin III family protein	-
AL479_RS04945	1033856..1034167	-	312	WP_061075277.1	N(4)-acetylcytidine aminohydrolase	-
AL479_RS04950	1034220..1034948	+	729	WP_061075278.1	MurR/RpiR family transcriptional regulator	-
AL479_RS04955	1035068..1036501	+	1434	WP_061075279.1	6-phospho-beta-glucosidase BglA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 15903.83 Da
• Isoelectric Point: 11.3523

>T59892 WP_061075274.1 NZ_CP014015:c1031468-1031061 [Citrobacter amalonaticus]
VVLWQSDLRVSWRAQWLSLLLHGLVAAAILLMPWPLSYTPLWLILLSLVVFDCVRSQRRINARQGEVKLLMDGRLRWQGQ
DWLIVNAPWMIKTGMMLRLRSDTGKRQHLWLAADSMDDAEWRDLRRLMIQQSKQG

Nucleotide

• Length: 408 bp

>T59892 NZ_CP014015:c1031468-1031061 [Citrobacter amalonaticus]
GTGGTCCTGTGGCAATCTGATCTCCGCGTCTCATGGCGCGCACAGTGGCTATCACTACTCCTGCATGGGCTGGTGGCCGC
GGCTATTCTCTTAATGCCATGGCCGCTGAGTTACACGCCGTTGTGGTTGATACTGCTTTCGCTGGTGGTGTTTGACTGTG
TCCGCAGCCAGCGACGAATTAACGCCCGTCAGGGGGAGGTCAAACTTCTGATGGATGGACGGCTCCGCTGGCAGGGGCAG
GACTGGCTTATCGTCAATGCACCGTGGATGATCAAAACCGGCATGATGCTGCGTCTGCGATCAGATACCGGTAAACGCCA
GCATTTGTGGCTCGCGGCTGACAGTATGGATGACGCGGAATGGCGGGATTTACGCCGCCTGATGATTCAACAGTCGAAGC
AAGGGTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10544.06 Da
• Isoelectric Point: 5.1496

>AT59892 WP_042322123.1 NZ_CP014015:c1031715-1031449 [Citrobacter amalonaticus]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RDRGPVAI

Nucleotide

• Length: 267 bp

>AT59892 NZ_CP014015:c1031715-1031449 [Citrobacter amalonaticus]
ATGGATATTAACAATAAAGCACGTATTCACTGGGCATGCCGACGCGGTATGCGTGAACTCGATATTTCCATCATGCCGTT
TTTCGAACATGAATACGACACGTTGAGTGATGATGAAAAGCGTATTTTTATCCGCCTGCTGGAGTGTGATGACCCGGACT
TATTCAACTGGTTGATGAATCACGGTAAACCGGCAGATGCTGAACTGGAGCAGATGGTTCGACTCATCCAGACACGGAAT
CGGGATCGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0F6TWP9