Detailed information of TA system TA059889

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 2937085..2937746
• Replicon: chromosome
• Accession: NZ_CP014013
• Organism: Bordetella bronchiseptica strain FDAARGOS_176

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0H3LNE0
• Locus tag: AL472_RS14050
• Protein ID: WP_010926525.1
• Coordinates: 2937085..2937510 (-)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: AL472_RS14055
• Protein ID: WP_003812071.1
• Coordinates: 2937507..2937746 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AL472_RS14030	2932899..2933876	+	978	WP_003812083.1	tripartite tricarboxylate transporter substrate binding protein	-
AL472_RS14035	2933897..2934409	-	513	WP_003812080.1	hypothetical protein	-
AL472_RS14040	2934908..2936413	+	1506	WP_003812078.1	tripartite tricarboxylate transporter permease	-
AL472_RS14045	2936511..2936975	-	465	WP_003812075.1	MarR family transcriptional regulator	-
AL472_RS14050	2937085..2937510	-	426	WP_010926525.1	PIN domain-containing protein	Toxin
AL472_RS14055	2937507..2937746	-	240	WP_003812071.1	Arc family DNA-binding protein	Antitoxin
AL472_RS14060	2937820..2938662	-	843	WP_003812068.1	AraC family transcriptional regulator	-
AL472_RS14065	2938800..2939345	+	546	WP_003812065.1	peroxidase-related enzyme	-
AL472_RS14070	2939404..2939916	+	513	WP_010926526.1	redoxin domain-containing protein	-
AL472_RS14075	2939997..2940230	+	234	WP_033447224.1	DUF2945 domain-containing protein	-
AL472_RS14080	2940227..2940787	+	561	WP_010926528.1	DUF488 domain-containing protein	-
AL472_RS14085	2940865..2941911	+	1047	WP_010926529.1	Dyp-type peroxidase	-
AL472_RS14090	2941908..2942711	+	804	WP_003812055.1	bacteriocin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

• Arc-like DNA binding domain (9-46)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 14811.22 Da
• Isoelectric Point: 6.3704

>T59889 WP_010926525.1 NZ_CP014013:c2937510-2937085 [Bordetella bronchiseptica]
MILLDTDVLLEPLRPAPDPAVAAWLDGQHVETLYLAAPGAAEIQLGLARLPRGKRAEALRHEFERRILPLFMGHVLPFDT
AAADAYAAVMMRAAAAGHALCAIDGCIAAIATAHGLAIATRHPARFEAAGLAAVDPWHAAA

Nucleotide

• Length: 426 bp

>T59889 NZ_CP014013:c2937510-2937085 [Bordetella bronchiseptica]
ATGATCCTGCTCGACACCGACGTGCTGCTCGAGCCGCTGCGGCCGGCCCCCGACCCGGCCGTCGCGGCATGGCTGGATGG
CCAGCACGTCGAAACCCTGTACCTGGCCGCGCCCGGCGCGGCCGAAATCCAGCTCGGGCTGGCCCGCCTGCCGCGCGGCA
AGCGGGCCGAGGCCCTGCGCCACGAATTCGAGCGGCGCATCCTGCCGCTGTTCATGGGCCATGTCCTGCCCTTCGACACG
GCCGCGGCCGATGCCTACGCCGCCGTCATGATGCGGGCCGCGGCGGCGGGCCATGCGCTGTGCGCAATCGATGGCTGCAT
CGCCGCCATCGCCACCGCGCACGGCCTGGCCATCGCCACGCGCCATCCGGCCAGGTTCGAGGCGGCCGGGCTCGCCGCCG
TCGATCCCTGGCACGCCGCCGCTTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8561.78 Da
• Isoelectric Point: 11.5658

>AT59889 WP_003812071.1 NZ_CP014013:c2937746-2937507 [Bordetella bronchiseptica]
VSSITVRNVPEEVHRALRVRAATHGRSTEAEIRAILENAVLPDGRVKLGTLLSHIGRGARGMDLTIERNPAPARPASFE

Nucleotide

• Length: 240 bp

>AT59889 NZ_CP014013:c2937746-2937507 [Bordetella bronchiseptica]
GTGTCTTCGATTACGGTAAGAAATGTTCCCGAGGAAGTGCATCGCGCCTTGCGCGTACGCGCGGCCACGCATGGGCGCAG
CACCGAGGCCGAGATCCGCGCCATCCTGGAAAACGCCGTGCTGCCCGATGGCCGCGTCAAGCTGGGCACCCTGCTCAGCC
ACATCGGCCGGGGCGCGCGCGGCATGGACCTGACCATCGAGCGCAATCCGGCGCCCGCCCGCCCGGCCAGCTTCGAATGA

Structures

Toxin

• AlphaFold DB: A0A0H3LNE0