Detailed information of TA system TA059848

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 578100..578920
• Replicon: chromosome
• Accession: NZ_CP014008
• Organism: Klebsiella pneumoniae subsp. pneumoniae strain RJF293

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: -
• Locus tag: RJF2_RS02835
• Protein ID: WP_060175518.1
• Coordinates: 578663..578920 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: RJF2_RS02830
• Protein ID: WP_060175517.1
• Coordinates: 578100..578651 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RJF2_RS02805	573997..574512	+	516	WP_032689729.1	hypothetical protein	-
RJF2_RS02810	574594..575565	+	972	WP_060175514.1	toll/interleukin-1 receptor domain-containing protein	-
RJF2_RS02815	575582..575905	+	324	WP_060175515.1	hypothetical protein	-
RJF2_RS26840	576149..576561	-	413	Protein_505	hypothetical protein	-
RJF2_RS28950	576623..577033	+	411	WP_186987065.1	hypothetical protein	-
RJF2_RS26845	576923..577174	-	252	WP_071888303.1	hypothetical protein	-
RJF2_RS02825	577302..578048	-	747	WP_060175516.1	class I SAM-dependent methyltransferase	-
RJF2_RS02830	578100..578651	-	552	WP_060175517.1	N-acetyltransferase	Antitoxin
RJF2_RS02835	578663..578920	-	258	WP_060175518.1	YjhX family toxin	Toxin
RJF2_RS02840	579231..579623	-	393	WP_060175519.1	VOC family protein	-
RJF2_RS02845	579633..580904	-	1272	WP_060175520.1	multidrug efflux MFS transporter MdtM	-
RJF2_RS02850	580944..581516	-	573	WP_060175521.1	DUF1349 domain-containing protein	-
RJF2_RS02855	581557..582375	-	819	WP_060175522.1	GNAT family N-acetyltransferase	-
RJF2_RS02860	582436..582870	-	435	WP_049047829.1	VOC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	564594..609498	44904

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (19-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9533.02 Da
• Isoelectric Point: 10.9373

>T59848 WP_060175518.1 NZ_CP014008:c578920-578663 [Klebsiella pneumoniae subsp. pneumoniae]
MNLSRQEQRTLHVLAKGGHIAHVRDASGRVTAVECYTREGLLLTDCTLATFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T59848 NZ_CP014008:c578920-578663 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAATTTATCCCGTCAGGAACAACGTACCTTACACGTTCTCGCCAAAGGTGGCCATATTGCGCACGTCCGCGATGCGTC
TGGCCGCGTCACCGCCGTTGAATGCTACACCCGCGAAGGGCTGTTGCTCACCGACTGCACCCTTGCCACCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGTCAGCCCTATCGAATCAACACTACCGGGTTGAATAACGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20360.32 Da
• Isoelectric Point: 6.4182

>AT59848 WP_060175517.1 NZ_CP014008:c578651-578100 [Klebsiella pneumoniae subsp. pneumoniae]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRSMGCQIVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMNVTGHIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT59848 NZ_CP014008:c578651-578100 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACAGCACACCATTTCACTTTTCAAATCACAGATGAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAACGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCTGCGTTATCGCTGCTGGCCC
GACATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGCTGATGCAT
ATCCTCGCTCCTCTGGCGGTCATACCGGAATACCAGGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGATCGATGGGCTGCCAGATAGTATTTGTTCTCGGCCACGCCACCTATTACCCCAGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGAACGTGACCGGCCACATCCAGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA