Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 4669625..4670270 Replicon chromosome
Accession NZ_CP014007
Organism Kosakonia oryzae strain Ola 51

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag AWR26_RS21875 Protein ID WP_035886605.1
Coordinates 4669625..4669807 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag AWR26_RS21880 Protein ID WP_035943124.1
Coordinates 4669833..4670270 (+) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AWR26_RS21850 4664708..4665661 - 954 WP_064568546.1 AraC family transcriptional regulator -
AWR26_RS21855 4665780..4666685 - 906 WP_064568547.1 LysR family transcriptional regulator -
AWR26_RS21860 4666772..4667557 + 786 WP_064568548.1 NAD(P)H-dependent oxidoreductase -
AWR26_RS21865 4667749..4668321 + 573 WP_064568549.1 TetR/AcrR family transcriptional regulator -
AWR26_RS21870 4668388..4669554 + 1167 WP_064568550.1 multidrug effflux MFS transporter -
AWR26_RS21875 4669625..4669807 + 183 WP_035886605.1 type II toxin-antitoxin system HicA family toxin Toxin
AWR26_RS21880 4669833..4670270 + 438 WP_035943124.1 hypothetical protein Antitoxin
AWR26_RS21885 4670267..4671160 - 894 WP_064568551.1 MurR/RpiR family transcriptional regulator -
AWR26_RS21890 4671173..4672120 - 948 WP_064568552.1 iron-siderophore ABC transporter substrate-binding protein -
AWR26_RS21895 4672135..4673187 - 1053 WP_064568553.1 iron ABC transporter permease -
AWR26_RS21900 4673184..4674209 - 1026 WP_064568554.1 iron ABC transporter permease -
AWR26_RS21905 4674206..4675030 - 825 WP_064568555.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-82)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6770.97 Da        Isoelectric Point: 11.0174

>T59842 WP_035886605.1 NZ_CP014007:4669625-4669807 [Kosakonia oryzae]
MKYSEFRKWLLSQGAELTKAPGGGSHFKVRLNGRASVFPFHGSKEIPEPLRKKIMKDLGL

Download         Length: 183 bp

>T59842 NZ_CP014007:4669625-4669807 [Kosakonia oryzae]
ATGAAATACAGCGAGTTCAGAAAGTGGTTGTTATCTCAGGGAGCGGAGCTAACCAAAGCTCCAGGTGGAGGAAGCCATTT
TAAAGTCAGGCTTAATGGTAGGGCATCGGTTTTCCCTTTTCATGGTTCGAAAGAGATTCCTGAGCCGTTGAGGAAAAAGA
TTATGAAGGACTTAGGCCTGTAA

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 15953.41 Da        Isoelectric Point: 5.5739

>AT59842 WP_035943124.1 NZ_CP014007:4669833-4670270 [Kosakonia oryzae]
MFNYPVHIERDDATGQFVVSCRDLPLMNSVGDTLDEALLQSIDGIVVAIAIEIDERRPIPAASAPLKGEYIVSLPVLVAM
KAALHNAMIETGTRKAELARKLGQKGPQIDRLLDVEHSSKVETVELALHQLNRQIDLTITPQHRA

Download         Length: 438 bp

>AT59842 NZ_CP014007:4669833-4670270 [Kosakonia oryzae]
ATGTTTAATTATCCCGTCCACATTGAACGAGACGATGCTACAGGTCAGTTCGTGGTCTCATGCCGCGATCTACCGCTCAT
GAACTCCGTTGGCGATACGCTTGATGAGGCTTTACTGCAGTCGATTGATGGGATTGTTGTTGCGATTGCTATCGAAATTG
ACGAGCGGCGTCCAATCCCGGCGGCAAGCGCGCCGCTAAAAGGCGAATACATCGTATCGCTGCCCGTGCTCGTAGCCATG
AAAGCCGCACTGCATAACGCCATGATCGAAACCGGGACGCGAAAAGCTGAGCTGGCAAGAAAGCTGGGACAGAAAGGGCC
GCAAATTGACCGCTTGCTCGATGTGGAGCACTCATCGAAGGTGGAAACGGTTGAACTGGCGCTACATCAGTTAAATCGAC
AGATTGATCTGACCATTACGCCGCAGCACAGAGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References