Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4065523..4066138 Replicon chromosome
Accession NZ_CP014007
Organism Kosakonia oryzae strain Ola 51

Toxin (Protein)


Gene name Hha Uniprot ID A0A1C4FBY4
Locus tag AWR26_RS19080 Protein ID WP_007373583.1
Coordinates 4065920..4066138 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A6M5CWA9
Locus tag AWR26_RS19075 Protein ID WP_007373584.1
Coordinates 4065523..4065897 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AWR26_RS19065 4060645..4061838 + 1194 WP_043954577.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
AWR26_RS19070 4061861..4065010 + 3150 WP_064568149.1 multidrug efflux RND transporter permease subunit AcrB -
AWR26_RS19075 4065523..4065897 + 375 WP_007373584.1 Hha toxicity modulator TomB Antitoxin
AWR26_RS19080 4065920..4066138 + 219 WP_007373583.1 hemolysin expression modulator Hha Toxin
AWR26_RS19085 4066204..4066764 + 561 WP_064568150.1 maltose O-acetyltransferase -
AWR26_RS19090 4066865..4067344 + 480 WP_064568151.1 YlaC family protein -
AWR26_RS19095 4067310..4068755 - 1446 WP_064568152.1 PLP-dependent aminotransferase family protein -
AWR26_RS19100 4068853..4069554 + 702 WP_064568153.1 GNAT family N-acetyltransferase -
AWR26_RS19105 4069551..4069691 - 141 WP_007373577.1 type B 50S ribosomal protein L36 -
AWR26_RS19110 4069695..4069955 - 261 WP_043954585.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8637.05 Da        Isoelectric Point: 7.9893

>T59841 WP_007373583.1 NZ_CP014007:4065920-4066138 [Kosakonia oryzae]
MSEKPLTKVDYLMRLRRCQTIDTLERVIEKNKYELPDEELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T59841 NZ_CP014007:4065920-4066138 [Kosakonia oryzae]
ATGTCCGAAAAACCATTAACAAAAGTTGATTATTTGATGCGTCTCAGACGTTGTCAGACAATTGATACCCTTGAACGTGT
AATTGAAAAAAATAAATACGAACTTCCGGATGAGGAACTCGCGGTGTTTTATTCAGCAGCCGATCATCGCCTGGCAGAAC
TGACCATGAATAAGCTGTATGACAAAATCCCCTCCTCCGTGTGGAAATTTGTACGATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14567.42 Da        Isoelectric Point: 5.8339

>AT59841 WP_007373584.1 NZ_CP014007:4065523-4065897 [Kosakonia oryzae]
MDEYSPKRHDIAQLKFLCETLYHDCLVNLEESHHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINTHDLQKWRKTGNKLFRCFVNVSKANPVSHSC

Download         Length: 375 bp

>AT59841 NZ_CP014007:4065523-4065897 [Kosakonia oryzae]
ATGGACGAATACTCGCCAAAAAGGCATGATATCGCGCAGCTCAAATTTCTCTGCGAAACGCTGTACCATGACTGCCTTGT
TAATCTCGAAGAGAGCCATCATGGGTGGGTTAACGATCCTACATCAGCGGTCAATTTGCAGTTAAATGAGCTGATAGAAC
ACATAGCGACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAACTGATTGAACAGATAGACGAATATCTT
GACGATACGTTTATGTTGTTCAGTAGCTATGGCATAAATACACATGACTTACAGAAATGGCGCAAAACAGGCAACAAACT
GTTCCGCTGCTTCGTCAATGTAAGCAAGGCTAATCCAGTTAGCCACTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1C4FBY4

Antitoxin

Source ID Structure
AlphaFold DB A0A6M5CWA9

References