Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazE-MazF
Location 1251073..1251650 Replicon chromosome
Accession NZ_CP013998
Organism Synechococcus sp. PCC 73109

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag AWQ23_RS06045 Protein ID WP_030006279.1
Coordinates 1251073..1251333 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag AWQ23_RS06050 Protein ID WP_062433491.1
Coordinates 1251321..1251650 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AWQ23_RS06025 1246242..1247741 - 1500 WP_062433487.1 AAA family ATPase -
AWQ23_RS06030 1247845..1248183 - 339 WP_030006276.1 hypothetical protein -
AWQ23_RS06035 1248432..1249730 + 1299 WP_012306805.1 FIST C-terminal domain-containing protein -
AWQ23_RS06040 1249743..1250933 - 1191 WP_062433489.1 class I SAM-dependent rRNA methyltransferase -
AWQ23_RS06045 1251073..1251333 + 261 WP_030006279.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Toxin
AWQ23_RS06050 1251321..1251650 + 330 WP_062433491.1 type II toxin-antitoxin system PemK/MazF family toxin Antitoxin
AWQ23_RS06055 1251959..1253401 + 1443 WP_062433493.1 sodium:glutamate symporter -
AWQ23_RS06060 1253410..1253985 - 576 WP_157072196.1 hypothetical protein -
AWQ23_RS06065 1254305..1255273 - 969 WP_062433496.1 integron integrase -
AWQ23_RS06070 1255461..1255805 + 345 WP_062433499.1 hypothetical protein -
AWQ23_RS06075 1255805..1256287 + 483 WP_062433502.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

SpoVT-AbrB domain

(10-50)

Antitoxin

mRNA interferase PemK-like

(6-107)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 9877.06 Da        Isoelectric Point: 4.3646

>T59806 WP_030006279.1 NZ_CP013998:1251073-1251333 [Synechococcus sp. PCC 73109]
MGAVIRTRIVKIGNSQGIRIPKLLLEQSGIDTEVEIEVQGDHLTIRTAPRSRRGWDEAFSAMAQRQDDILLDEVNATDWD
QTEWEW

Download         Length: 261 bp

>T59806 NZ_CP013998:1251073-1251333 [Synechococcus sp. PCC 73109]
ATGGGCGCAGTCATTCGAACCCGCATCGTAAAAATTGGGAATTCCCAAGGCATTCGTATTCCCAAGCTACTTTTAGAACA
AAGTGGCATTGACACAGAAGTTGAAATTGAAGTGCAAGGCGACCATCTAACCATTCGCACGGCCCCCCGCTCACGCCGAG
GCTGGGATGAAGCTTTTTCGGCAATGGCTCAGCGACAGGATGATATTTTGTTGGACGAAGTTAATGCTACCGATTGGGAT
CAAACAGAATGGGAATGGTAG

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12210.27 Da        Isoelectric Point: 8.2775

>AT59806 WP_062433491.1 NZ_CP013998:1251321-1251650 [Synechococcus sp. PCC 73109]
MGMVAKRFDVFLVNLDPTVGSEIQKTRPCVIISPDEMNCHIATVIVAPMTTKGRAYPTRVTCQFQGKSGQIVLDQIRTID
KSRLVKKLGQINQDEQRTVLETLAEMFAE

Download         Length: 330 bp

>AT59806 NZ_CP013998:1251321-1251650 [Synechococcus sp. PCC 73109]
ATGGGAATGGTAGCCAAACGTTTTGATGTTTTTTTGGTGAATCTCGATCCCACCGTCGGTAGTGAAATCCAAAAGACACG
ACCCTGTGTGATCATTTCGCCAGATGAGATGAACTGCCATATCGCGACGGTAATTGTTGCGCCAATGACAACGAAAGGAA
GAGCCTATCCGACTCGTGTTACGTGTCAGTTTCAGGGTAAAAGTGGGCAAATTGTTCTGGATCAAATCCGTACAATTGAT
AAGTCTCGACTCGTCAAAAAGCTGGGTCAAATTAATCAAGATGAACAAAGAACAGTGCTTGAAACTTTGGCGGAGATGTT
TGCTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References