Detailed information of TA system TA059806

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazE-MazF
• Location: 1251073..1251650
• Replicon: chromosome
• Accession: NZ_CP013998
• Organism: Synechococcus sp. PCC 73109

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: AWQ23_RS06045
• Protein ID: WP_030006279.1
• Coordinates: 1251073..1251333 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: AWQ23_RS06050
• Protein ID: WP_062433491.1
• Coordinates: 1251321..1251650 (+)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AWQ23_RS06025	1246242..1247741	-	1500	WP_062433487.1	AAA family ATPase	-
AWQ23_RS06030	1247845..1248183	-	339	WP_030006276.1	hypothetical protein	-
AWQ23_RS06035	1248432..1249730	+	1299	WP_012306805.1	FIST C-terminal domain-containing protein	-
AWQ23_RS06040	1249743..1250933	-	1191	WP_062433489.1	class I SAM-dependent rRNA methyltransferase	-
AWQ23_RS06045	1251073..1251333	+	261	WP_030006279.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Toxin
AWQ23_RS06050	1251321..1251650	+	330	WP_062433491.1	type II toxin-antitoxin system PemK/MazF family toxin	Antitoxin
AWQ23_RS06055	1251959..1253401	+	1443	WP_062433493.1	sodium:glutamate symporter	-
AWQ23_RS06060	1253410..1253985	-	576	WP_157072196.1	hypothetical protein	-
AWQ23_RS06065	1254305..1255273	-	969	WP_062433496.1	integron integrase	-
AWQ23_RS06070	1255461..1255805	+	345	WP_062433499.1	hypothetical protein	-
AWQ23_RS06075	1255805..1256287	+	483	WP_062433502.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• SpoVT-AbrB domain (10-50)

Antitoxin

• mRNA interferase PemK-like (6-107)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 9877.06 Da
• Isoelectric Point: 4.3646

>T59806 WP_030006279.1 NZ_CP013998:1251073-1251333 [Synechococcus sp. PCC 73109]
MGAVIRTRIVKIGNSQGIRIPKLLLEQSGIDTEVEIEVQGDHLTIRTAPRSRRGWDEAFSAMAQRQDDILLDEVNATDWD
QTEWEW

Nucleotide

• Length: 261 bp

>T59806 NZ_CP013998:1251073-1251333 [Synechococcus sp. PCC 73109]
ATGGGCGCAGTCATTCGAACCCGCATCGTAAAAATTGGGAATTCCCAAGGCATTCGTATTCCCAAGCTACTTTTAGAACA
AAGTGGCATTGACACAGAAGTTGAAATTGAAGTGCAAGGCGACCATCTAACCATTCGCACGGCCCCCCGCTCACGCCGAG
GCTGGGATGAAGCTTTTTCGGCAATGGCTCAGCGACAGGATGATATTTTGTTGGACGAAGTTAATGCTACCGATTGGGAT
CAAACAGAATGGGAATGGTAG

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 12210.27 Da
• Isoelectric Point: 8.2775

>AT59806 WP_062433491.1 NZ_CP013998:1251321-1251650 [Synechococcus sp. PCC 73109]
MGMVAKRFDVFLVNLDPTVGSEIQKTRPCVIISPDEMNCHIATVIVAPMTTKGRAYPTRVTCQFQGKSGQIVLDQIRTID
KSRLVKKLGQINQDEQRTVLETLAEMFAE

Nucleotide

• Length: 330 bp

>AT59806 NZ_CP013998:1251321-1251650 [Synechococcus sp. PCC 73109]
ATGGGAATGGTAGCCAAACGTTTTGATGTTTTTTTGGTGAATCTCGATCCCACCGTCGGTAGTGAAATCCAAAAGACACG
ACCCTGTGTGATCATTTCGCCAGATGAGATGAACTGCCATATCGCGACGGTAATTGTTGCGCCAATGACAACGAAAGGAA
GAGCCTATCCGACTCGTGTTACGTGTCAGTTTCAGGGTAAAAGTGGGCAAATTGTTCTGGATCAAATCCGTACAATTGAT
AAGTCTCGACTCGTCAAAAAGCTGGGTCAAATTAATCAAGATGAACAAAGAACAGTGCTTGAAACTTTGGCGGAGATGTT
TGCTGAGTGA