Detailed information of TA system TA059797

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4852870..4854128
• Replicon: chromosome
• Accession: NZ_CP013993
• Organism: Pseudomonas aeruginosa DHS01 strain DH01

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A241XTS2
• Locus tag: DPADHS01_RS22865
• Protein ID: WP_023464370.1
• Coordinates: 4852870..4853625 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A241XST8
• Locus tag: DPADHS01_RS22870
• Protein ID: WP_023464369.1
• Coordinates: 4853760..4854128 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DPADHS01_RS22855	4848041..4850584	+	2544	WP_023464371.1	acyl-homoserine-lactone acylase QuiP	-
DPADHS01_RS22860	4850739..4852100	-	1362	WP_003081943.1	DNA recombination protein RmuC	-
DPADHS01_RS22865	4852870..4853625	-	756	WP_023464370.1	RES family NAD+ phosphorylase	Toxin
DPADHS01_RS22870	4853760..4854128	-	369	WP_023464369.1	DUF2384 domain-containing protein	Antitoxin
DPADHS01_RS22875	4854201..4855487	-	1287	WP_023464368.1	FAD-binding oxidoreductase	-
DPADHS01_RS22880	4855543..4857132	-	1590	WP_023464367.1	aldehyde dehydrogenase family protein	-
DPADHS01_RS22885	4857210..4857686	+	477	WP_019725934.1	hypothetical protein	-
DPADHS01_RS35365	4857689..4857964	-	276	WP_010792073.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28226.37 Da
• Isoelectric Point: 7.6839

>T59797 WP_023464370.1 NZ_CP013993:c4853625-4852870 [Pseudomonas aeruginosa DHS01]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAECAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRASQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGAPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T59797 NZ_CP013993:c4853625-4852870 [Pseudomonas aeruginosa DHS01]
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATGTCCGACCGCTCCAGGGGCGGCTGGTACGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGACACCCTGGAAGAACAGGCGTTGCTCGAGGAACTGCTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGATGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGTTGGGGG
TCGCGGTTTGGCCGTCGTCACGAGCCAAGCCTGTTCTACGCCGCGTTGAAGCTGGAAACGGCCATGGCCGAATGCGCGTA
TTACCGTTGTGTCCTGTGGAGTGGCATGGCGGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATCCGTCTGCAGGCGCCGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTTCCCAGGAACTGGGAAGTGCCATGCGCAGCGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGTCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCCTTCAAGCCGGCGCATGTGCCGGGGGCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGGACGGAAAGTTGCCGCATCCGGCGTGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13395.68 Da
• Isoelectric Point: 9.9874

>AT59797 WP_023464369.1 NZ_CP013993:c4854128-4853760 [Pseudomonas aeruginosa DHS01]
MSVLIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT59797 NZ_CP013993:c4854128-4853760 [Pseudomonas aeruginosa DHS01]
ATGAGCGTTCTCATCAAGGAACGTCCCAGCGCCGATGCTGTCCTGGCCAAGGCCGTCCTGGCCGCGCGCGAGCAATTGGG
GCTGACGCAGCTCGAACTGGCCGGCATCGTCGGCGTCGATCGCAGCGCCATCAGCCGCTGGAAGACCCAGGGCCTGCGGG
TGGACAGCAAGACCGGCGAGCTGGCTCTGCTGCTGGTGCGAGTCTATCGCGCACTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACATGCGCCACTTCCTGCGCACTCCCAACCATCACCTGGCGGGCGAGCCGCTGGCACTGATGGGACAGGTGCAGGG
CCTGGTTCATGTGCTGGAATACCTCGATGCGATCCGCGGCAAGGTCTGA

Structures

Toxin

• AlphaFold DB: A0A241XTS2

Antitoxin

• AlphaFold DB: A0A241XST8