59795

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/RHH(antitoxin)
Location 2700658..2701211 Replicon chromosome
Accession NZ_CP013993
Organism Pseudomonas aeruginosa DHS01 strain DH01

Toxin (Protein)


Gene name parE Uniprot ID Q88JZ3
Locus tag DPADHS01_RS33755 Protein ID WP_010953434.1
Coordinates 2700918..2701211 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q88JZ4
Locus tag DPADHS01_RS13040 Protein ID WP_010953433.1
Coordinates 2700658..2700930 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DPADHS01_RS13010 2696230..2696589 - 360 Protein_2607 DNA repair protein RadC -
DPADHS01_RS13015 2696561..2697511 - 951 WP_031299400.1 hypothetical protein -
DPADHS01_RS13020 2697604..2698608 - 1005 WP_010953429.1 YqaJ viral recombinase family protein -
DPADHS01_RS13025 2698688..2699656 - 969 WP_031299399.1 DUF932 domain-containing protein -
DPADHS01_RS13030 2699754..2700026 - 273 WP_031299398.1 hypothetical protein -
DPADHS01_RS13035 2700288..2700533 + 246 WP_010953432.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
DPADHS01_RS13040 2700658..2700930 + 273 WP_010953433.1 CopG family ribbon-helix-helix protein Antitoxin
DPADHS01_RS33755 2700918..2701211 + 294 WP_010953434.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DPADHS01_RS13045 2701205..2702614 - 1410 WP_010953435.1 site-specific integrase -
DPADHS01_RS13050 2703052..2705832 + 2781 WP_023464835.1 DEAD/DEAH box helicase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2671244..2723680 52436


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-95)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11155.61 Da        Isoelectric Point: 5.9081

>T59795 WP_010953434.1 NZ_CP013993:2700918-2701211 [Pseudomonas aeruginosa DHS01]
VPRLIVTEGAAKGLERCRRFLSDKDPQVARRAAQAIERQFARLEESPEVGRPFPDLPELRELIIEFGDSGYVALYRYERA
DDTAYVLAFRHQKEAGY

Download         Length: 294 bp

>T59795 NZ_CP013993:2700918-2701211 [Pseudomonas aeruginosa DHS01]
GTGCCACGACTGATCGTCACTGAAGGCGCGGCGAAGGGCCTGGAGCGTTGCCGGCGATTTCTCTCCGATAAAGATCCGCA
GGTCGCACGCCGTGCTGCACAGGCAATCGAGCGCCAATTCGCTCGATTGGAGGAAAGTCCGGAAGTAGGGCGTCCTTTTC
CAGATCTGCCAGAGCTGCGTGAGCTCATCATCGAGTTTGGTGACTCAGGTTACGTCGCGCTGTACCGCTATGAGCGCGCA
GATGACACCGCCTATGTCTTGGCCTTTCGCCATCAAAAAGAAGCTGGCTACTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10373.53 Da        Isoelectric Point: 5.5744

>AT59795 WP_010953433.1 NZ_CP013993:2700658-2700930 [Pseudomonas aeruginosa DHS01]
MATSIKIDDDLKGRIQHLACLRQRSSHWIMREAITQYVEREEARESFKQEALASWAAYQETGQHLTGQEARTWLGSWGTD
AEAELPKCHD

Download         Length: 273 bp

>AT59795 NZ_CP013993:2700658-2700930 [Pseudomonas aeruginosa DHS01]
ATGGCCACTTCCATCAAAATTGACGACGATCTGAAAGGTCGCATTCAGCATTTGGCTTGTTTGCGCCAGCGCTCATCTCA
CTGGATCATGCGTGAGGCGATCACCCAGTACGTCGAGCGTGAGGAGGCCCGTGAGAGCTTCAAACAAGAAGCGCTGGCAT
CTTGGGCTGCATACCAGGAAACCGGCCAGCACTTGACCGGCCAGGAGGCTCGCACCTGGCTTGGTAGTTGGGGTACAGAT
GCTGAGGCAGAGTTACCCAAGTGCCACGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W5CNE8

Antitoxin

Source ID Structure
AlphaFold DB Q88JZ4

References