Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 927656..928313 Replicon chromosome
Accession NZ_CP013993
Organism Pseudomonas aeruginosa DHS01 strain DH01

Toxin (Protein)


Gene name hicA Uniprot ID A0A8G3IXE4
Locus tag DPADHS01_RS04370 Protein ID WP_003098540.1
Coordinates 928131..928313 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag DPADHS01_RS04365 Protein ID WP_003124172.1
Coordinates 927656..928084 (-) Length 143 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DPADHS01_RS04335 923266..923496 + 231 WP_023124259.1 hypothetical protein -
DPADHS01_RS04340 923493..924332 + 840 WP_033944546.1 helix-turn-helix domain-containing protein -
DPADHS01_RS04345 924244..925128 + 885 WP_191984976.1 ATP-binding protein -
DPADHS01_RS04350 925125..926522 + 1398 WP_033944544.1 AAA family ATPase -
DPADHS01_RS04355 926519..926803 + 285 WP_023835928.1 hypothetical protein -
DPADHS01_RS04360 926800..927357 + 558 WP_015980945.1 hypothetical protein -
DPADHS01_RS04365 927656..928084 - 429 WP_003124172.1 hypothetical protein Antitoxin
DPADHS01_RS04370 928131..928313 - 183 WP_003098540.1 type II toxin-antitoxin system HicA family toxin Toxin
DPADHS01_RS04375 928514..928828 + 315 WP_015649339.1 phage holin, lambda family -
DPADHS01_RS04380 928828..929445 + 618 WP_023465046.1 glycoside hydrolase family 19 protein -
DPADHS01_RS04385 929445..929915 + 471 WP_023465047.1 lysis system i-spanin subunit Rz -
DPADHS01_RS04390 929912..930655 + 744 WP_023835830.1 hypothetical protein -
DPADHS01_RS04395 930807..931352 + 546 WP_003159067.1 terminase small subunit -
DPADHS01_RS04400 931324..933288 + 1965 WP_023465049.1 phage terminase large subunit family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 905761..951335 45574


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(7-78)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6746.86 Da        Isoelectric Point: 11.0775

>T59793 WP_003098540.1 NZ_CP013993:c928313-928131 [Pseudomonas aeruginosa DHS01]
MKFSEFRRWLKAQGVTFEAGKGSHFKITAPNGKQTTFADHGAKEMPEPTRKAIIKQLGLK

Download         Length: 183 bp

>T59793 NZ_CP013993:c928313-928131 [Pseudomonas aeruginosa DHS01]
ATGAAGTTCAGCGAATTCAGACGATGGTTGAAGGCCCAAGGGGTGACCTTCGAAGCCGGCAAGGGAAGCCACTTCAAGAT
CACCGCCCCGAACGGCAAACAGACCACCTTCGCGGACCACGGAGCTAAGGAAATGCCAGAACCGACCCGCAAGGCGATCA
TCAAGCAACTGGGGCTCAAATGA

Antitoxin


Download         Length: 143 a.a.        Molecular weight: 15770.97 Da        Isoelectric Point: 4.6562

>AT59793 WP_003124172.1 NZ_CP013993:c928084-927656 [Pseudomonas aeruginosa DHS01]
MYDYAIRFEQDDSAPGVAVFCRDLPELNSYGDDKAHAISEAVDAIESTLSLYVDQRREIPAASQAQPGERVIHLPAVTVA
KVALWNEMIRRDMRKADLCRLLGIAQIQGDRLVDFLHNTKMEAMENALSALGLRLSVNIEAA

Download         Length: 429 bp

>AT59793 NZ_CP013993:c928084-927656 [Pseudomonas aeruginosa DHS01]
ATGTACGACTATGCAATCCGTTTCGAACAGGACGATAGCGCTCCTGGCGTCGCCGTTTTCTGCAGAGACCTGCCGGAACT
GAACAGCTACGGCGACGATAAGGCCCATGCAATCAGCGAGGCGGTTGACGCCATCGAGTCAACCCTCTCGCTGTACGTTG
ATCAGCGCCGAGAAATCCCCGCAGCCAGCCAGGCACAACCAGGCGAGCGCGTTATCCATCTGCCGGCGGTTACCGTTGCG
AAGGTCGCGCTCTGGAACGAAATGATCCGTCGAGATATGCGAAAAGCTGACCTCTGCCGGCTCCTCGGGATCGCGCAGAT
CCAGGGTGACAGGCTCGTCGACTTCCTCCACAACACCAAGATGGAAGCCATGGAGAACGCGCTATCCGCCCTCGGCCTCC
GCCTATCAGTGAATATCGAGGCGGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References