Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2444996..2446561 Replicon chromosome
Accession NZ_CP013990
Organism Leclercia adecarboxylata strain USDA-ARS-USMARC-60222

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag APT61_RS11315 Protein ID WP_059307940.1
Coordinates 2445251..2446561 (+) Length 437 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag APT61_RS11310 Protein ID WP_032618098.1
Coordinates 2444996..2445247 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APT61_RS11305 2440396..2444196 - 3801 Protein_2223 glycosyltransferase -
APT61_RS11310 2444996..2445247 + 252 WP_032618098.1 helix-turn-helix domain-containing protein Antitoxin
APT61_RS11315 2445251..2446561 + 1311 WP_059307940.1 type II toxin-antitoxin system HipA family toxin Toxin
APT61_RS11320 2446696..2447757 + 1062 WP_059307941.1 YncE family protein -
APT61_RS11325 2447768..2449765 + 1998 WP_059307942.1 TonB-dependent receptor -
APT61_RS11330 2449898..2451079 + 1182 WP_032618094.1 PLP-dependent aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-64)


Sequences

Toxin        


Download         Length: 437 a.a.        Molecular weight: 48202.42 Da        Isoelectric Point: 6.6977

>T59787 WP_059307940.1 NZ_CP013990:2445251-2446561 [Leclercia adecarboxylata]
MRAQRLTVAMNGDVVGTLHRDGSGAMSFQYAPEWLAEPGSRAISLSLPLQHGRIRGAQVFNFFSNLLPDSEAIIARMQAR
FQVETAHPFDLLASVGRDCVGAIQLYPPGQEIPPVTDIVAEPLDDDQIAALLDGYQMAPLGMTEEDADFRISLAGAQEKT
ALLWYQARWQRPQGSTPTSHIFKLPIGRIEQNNIDLSESCENEWLCLRIAKAFGFPVAQAEMATFGRKKVLIIERFDRRW
SSSGWLMRLPQEDFCQALGVSPALKYESHGGPGIADAMKLLLGSRLAGQDRELFFKAQILFWMLAAIDGHGKNFSLFIEA
DSAFRMAPLYDVISAFPLFDAGGIPVKKAKMAMALQGKNRQYHFAMIQPRHFISTAAFAGYSQEAVRRLLAEMAERTGDV
IASVRAELPSDFPMQVSEAIFKGLASQAARIGRFVS

Download         Length: 1311 bp

>T59787 NZ_CP013990:2445251-2446561 [Leclercia adecarboxylata]
ATGCGCGCACAACGACTGACTGTTGCGATGAATGGCGACGTAGTGGGTACGCTGCATCGTGACGGCAGCGGGGCGATGTC
CTTCCAGTATGCCCCGGAGTGGCTGGCCGAGCCGGGTTCGCGCGCGATTTCGCTCTCTTTACCACTACAGCACGGCAGGA
TCAGAGGCGCGCAGGTCTTTAATTTCTTCAGTAATCTGCTGCCTGACTCTGAGGCGATTATTGCCCGCATGCAGGCCCGA
TTCCAGGTTGAAACCGCTCATCCCTTTGATCTGCTGGCCAGTGTCGGGCGTGACTGTGTGGGCGCCATTCAGCTCTATCC
GCCGGGACAGGAGATCCCCCCGGTAACAGATATCGTGGCCGAACCGCTGGATGACGATCAGATTGCCGCGCTGCTCGACG
GGTATCAGATGGCACCGCTGGGGATGACCGAGGAGGATGCCGACTTTCGCATTTCGCTGGCCGGCGCGCAGGAAAAGACG
GCGCTGCTATGGTACCAGGCACGCTGGCAGCGGCCCCAGGGTAGCACCCCAACCAGTCACATCTTTAAGCTGCCGATCGG
CAGAATAGAACAAAACAATATCGACCTGAGCGAAAGTTGTGAAAACGAATGGCTGTGTTTGCGCATTGCCAAAGCCTTTG
GTTTCCCAGTGGCACAGGCGGAGATGGCAACCTTTGGCCGCAAGAAAGTGCTGATTATCGAGCGTTTCGACCGTCGTTGG
TCCAGCAGCGGGTGGCTGATGCGCCTGCCGCAGGAAGATTTTTGCCAGGCCCTGGGCGTGTCGCCAGCGCTGAAATATGA
ATCTCACGGTGGTCCCGGGATTGCCGACGCCATGAAGCTGCTGCTCGGTTCCCGCCTGGCGGGGCAGGATCGCGAGCTGT
TCTTTAAGGCGCAGATCCTGTTCTGGATGCTGGCCGCAATTGATGGTCACGGGAAGAATTTCAGCCTGTTTATCGAGGCG
GATTCCGCCTTTCGCATGGCCCCGCTGTACGACGTGATTTCCGCGTTTCCGCTGTTCGACGCAGGGGGGATCCCGGTCAA
AAAAGCGAAGATGGCGATGGCGTTACAGGGCAAGAACCGGCAGTACCATTTTGCGATGATCCAACCGCGTCACTTTATCA
GCACCGCAGCTTTTGCGGGGTATTCCCAGGAGGCCGTCCGCCGTTTGCTGGCCGAAATGGCAGAACGCACTGGCGACGTT
ATTGCCTCCGTCAGGGCAGAATTGCCATCGGATTTCCCCATGCAGGTCAGTGAGGCCATTTTTAAAGGTTTAGCCAGCCA
GGCGGCAAGAATAGGGCGGTTCGTGAGTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9223.56 Da        Isoelectric Point: 10.1945

>AT59787 WP_032618098.1 NZ_CP013990:2444996-2445247 [Leclercia adecarboxylata]
MKVTSADALAQAVRDQRKVNKLTQTATAEQVGIKQTTVSEFENKPGSTKLETLFKILSALDLELHVVKRGGTLPDNNAWK
KEW

Download         Length: 252 bp

>AT59787 NZ_CP013990:2444996-2445247 [Leclercia adecarboxylata]
ATGAAAGTTACATCGGCAGACGCACTGGCTCAGGCTGTCCGGGATCAGCGTAAGGTCAATAAGTTAACCCAAACGGCAAC
GGCTGAACAGGTGGGGATTAAACAAACCACGGTATCGGAATTCGAGAACAAACCAGGCTCTACCAAACTGGAAACCTTGT
TCAAAATCCTCTCGGCGCTGGATCTGGAGCTGCACGTGGTGAAACGAGGCGGCACGCTGCCGGATAACAATGCCTGGAAG
AAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References