Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 50582..51225 Replicon plasmid unnamed
Accession NZ_CP013986
Organism Klebsiella variicola strain LMG 23571

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag AWN63_RS28050 Protein ID WP_119867229.1
Coordinates 50809..51225 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag AWN63_RS28045 Protein ID WP_119867228.1
Coordinates 50582..50812 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AWN63_RS28025 45950..47092 - 1143 WP_119867224.1 toll/interleukin-1 receptor domain-containing protein -
AWN63_RS28030 47226..48842 - 1617 WP_119867225.1 patatin-like phospholipase family protein -
AWN63_RS28035 49004..49489 - 486 WP_119867226.1 TIR domain-containing protein -
AWN63_RS28040 49501..50028 - 528 WP_119867227.1 toll/interleukin-1 receptor domain-containing protein -
AWN63_RS28045 50582..50812 + 231 WP_119867228.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
AWN63_RS28050 50809..51225 + 417 WP_119867229.1 type II toxin-antitoxin system VapC family toxin Toxin
AWN63_RS28060 51729..52739 - 1011 WP_123797896.1 hypothetical protein -
AWN63_RS28065 53259..53489 + 231 WP_119867231.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
AWN63_RS28070 53486..53902 + 417 WP_119867232.1 type II toxin-antitoxin system VapC family toxin -
AWN63_RS28075 54044..54262 + 219 WP_119867233.1 hypothetical protein -
AWN63_RS28080 54341..54667 + 327 WP_123797897.1 hypothetical protein -
AWN63_RS28085 54907..55164 + 258 WP_119867235.1 hypothetical protein -
AWN63_RS28090 55164..55730 + 567 WP_119867236.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..163254 163254


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15082.51 Da        Isoelectric Point: 7.8595

>T59767 WP_119867229.1 NZ_CP013986:50809-51225 [Klebsiella variicola]
VNKTYMLDTNICSFIMREQPEAVIKRLEQAVLRNQRIVISAITYAELRFGATGPKASPRHIALVDAFCARLDAVLPWDRA
AVDATTDIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPGLMLEDWVK

Download         Length: 417 bp

>T59767 NZ_CP013986:50809-51225 [Klebsiella variicola]
GTGAACAAAACTTACATGCTCGATACCAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCGGTCATTAAGCGCCT
GGAGCAGGCGGTACTGCGCAATCAGCGTATCGTGATCTCCGCCATTACCTACGCGGAGCTGCGTTTCGGGGCCACCGGAC
CGAAGGCCTCACCGCGCCACATTGCGCTGGTTGACGCTTTCTGCGCCCGCCTCGATGCTGTCCTGCCTTGGGACCGCGCC
GCAGTGGACGCCACGACGGACATAAAAGTGGCGTTGCGGCTGGCCGGGACGCCTATTGGTCCGAATGACACGGCCATTGC
CGGGCACGCTATCGCCGCCGGCGCCATCCTAGTGACAAATAACACGCGGGAATTTGAACGGGTGCCGGGCCTGATGCTGG
AAGACTGGGTGAAGTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8682.75 Da        Isoelectric Point: 4.4563

>AT59767 WP_119867228.1 NZ_CP013986:50582-50812 [Klebsiella variicola]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQLEKADADFMADREDVVSDEGRFNL

Download         Length: 231 bp

>AT59767 NZ_CP013986:50582-50812 [Klebsiella variicola]
ATGCGCACAGTTTCAATTTTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGCGACCTGGATTTTGAGGGCGTCAG
TGAGCTGGAGATCGTCCGAGAAGGGGACAGCATCATCCTGCGCCCTGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTCG
AAAAGGCCGACGCGGACTTTATGGCGGATCGCGAGGACGTTGTCAGCGATGAAGGACGATTTAATCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References