Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 4965547..4966074 Replicon chromosome
Accession NZ_CP013985
Organism Klebsiella variicola strain LMG 23571

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag AWN63_RS24605 Protein ID WP_119867156.1
Coordinates 4965547..4965822 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag AWN63_RS24610 Protein ID WP_119867157.1
Coordinates 4965826..4966074 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AWN63_RS24590 4961554..4963233 + 1680 WP_119867154.1 glycoside hydrolase family 43 protein -
AWN63_RS24595 4963478..4964347 + 870 WP_087653704.1 HNH endonuclease -
AWN63_RS24600 4964628..4965425 - 798 WP_119867155.1 helix-turn-helix domain-containing protein -
AWN63_RS24605 4965547..4965822 - 276 WP_119867156.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AWN63_RS24610 4965826..4966074 - 249 WP_119867157.1 ribbon-helix-helix domain-containing protein Antitoxin
AWN63_RS24615 4966151..4966984 - 834 WP_119867158.1 DUF4942 domain-containing protein -
AWN63_RS24620 4967099..4967440 - 342 WP_119867159.1 TA system toxin CbtA family protein -
AWN63_RS24625 4967476..4967802 - 327 WP_119867160.1 type IV toxin-antitoxin system YeeU family antitoxin -
AWN63_RS24630 4967847..4968320 - 474 WP_119867161.1 DNA repair protein RadC -
AWN63_RS24635 4968391..4969212 - 822 WP_119867162.1 DUF945 domain-containing protein -
AWN63_RS24640 4969309..4969776 - 468 Protein_4721 hypothetical protein -
AWN63_RS24645 4969821..4970237 - 417 WP_119867209.1 hypothetical protein -
AWN63_RS24650 4970345..4971034 - 690 WP_119867163.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-44)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 11071.37 Da        Isoelectric Point: 4.5714

>T59763 WP_119867156.1 NZ_CP013985:c4965822-4965547 [Klebsiella variicola]
MEIYWTLKAQDDLERIYRFALQYSRQHADDVLDRLITGCADLATHPAIGAQQPWYEPREVRKVLFDDYEVHYELRDNDIY
IVDLWHTKEER

Download         Length: 276 bp

>T59763 NZ_CP013985:c4965822-4965547 [Klebsiella variicola]
ATGGAAATTTACTGGACGCTTAAAGCTCAGGATGACCTGGAACGTATCTACCGTTTCGCTCTTCAGTATAGCCGCCAGCA
CGCCGATGACGTTTTGGATCGCCTGATTACTGGCTGCGCTGACCTTGCAACGCATCCGGCAATTGGCGCACAGCAGCCTT
GGTATGAACCTCGGGAAGTCCGGAAAGTGTTATTTGATGATTACGAGGTTCACTACGAACTTCGTGACAATGACATCTAT
ATCGTGGATCTCTGGCATACCAAAGAAGAACGTTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9014.35 Da        Isoelectric Point: 8.8294

>AT59763 WP_119867157.1 NZ_CP013985:c4966074-4965826 [Klebsiella variicola]
MGSLTKQTISAQIPVELAAAVENLAIELDRSKSWIIKEALTNMLAERERRHQSIQAGLADVDAGRVVSHSNMVDFANRLK
KA

Download         Length: 249 bp

>AT59763 NZ_CP013985:c4966074-4965826 [Klebsiella variicola]
ATGGGTTCGCTTACTAAACAAACCATCAGCGCACAGATACCCGTTGAATTGGCTGCTGCTGTTGAGAATCTGGCAATTGA
GTTGGACCGTTCTAAGAGCTGGATTATTAAAGAAGCATTGACCAATATGCTGGCCGAACGAGAACGGCGTCATCAGAGTA
TCCAAGCAGGTCTTGCTGATGTGGATGCCGGTCGTGTGGTGAGTCATTCGAACATGGTGGATTTCGCTAACCGTTTAAAG
AAAGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References