Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 789863..790520 Replicon chromosome
Accession NZ_CP013985
Organism Klebsiella variicola strain LMG 23571

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag AWN63_RS03985 Protein ID WP_002916310.1
Coordinates 790110..790520 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag AWN63_RS03980 Protein ID WP_002916312.1
Coordinates 789863..790129 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AWN63_RS03955 785013..786446 - 1434 WP_119866734.1 6-phospho-beta-glucosidase BglA -
AWN63_RS03960 786566..787294 - 729 WP_012967245.1 MurR/RpiR family transcriptional regulator -
AWN63_RS03965 787345..787656 + 312 WP_109848735.1 N(4)-acetylcytidine aminohydrolase -
AWN63_RS03970 787819..788478 + 660 WP_008806429.1 hemolysin III family protein -
AWN63_RS03975 788634..789617 - 984 WP_119866735.1 tRNA-modifying protein YgfZ -
AWN63_RS03980 789863..790129 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
AWN63_RS03985 790110..790520 + 411 WP_002916310.1 protein YgfX Toxin
AWN63_RS03990 790527..791048 - 522 WP_008806427.1 flavodoxin FldB -
AWN63_RS03995 791149..792045 + 897 WP_008806426.1 site-specific tyrosine recombinase XerD -
AWN63_RS04000 792068..792781 + 714 WP_064166672.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AWN63_RS04005 792787..794520 + 1734 WP_049139238.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T59750 WP_002916310.1 NZ_CP013985:790110-790520 [Klebsiella variicola]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T59750 NZ_CP013985:790110-790520 [Klebsiella variicola]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTCCACGGCGTTGTGGCGGC
GCTGGTGCTGTTGGTTCCCTGGCCGCTAAGCTACACCCCGATCTGGCTGCTGCTGTTGTCGCTGGTAGTGTTTGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGAGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTCATCAATAGCGGTATGCTGCTGCGTTTACGCCATGTCGATACCCGGCGCGG
GCAGCATCTGTGGCTGGCGGCGGATAGCATGGATGCCGGAGAATGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT59750 WP_002916312.1 NZ_CP013985:789863-790129 [Klebsiella variicola]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT59750 NZ_CP013985:789863-790129 [Klebsiella variicola]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAACGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References