Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1788247..1788767 Replicon chromosome
Accession NZ_CP013980
Organism Staphylococcus equorum strain KM1031

Toxin (Protein)


Gene name TsdT Uniprot ID A0A192F7F2
Locus tag AWC34_RS08605 Protein ID WP_031266142.1
Coordinates 1788247..1788459 (-) Length 71 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID J9GWP4
Locus tag AWC34_RS08610 Protein ID WP_002507096.1
Coordinates 1788474..1788767 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AWC34_RS08590 1783822..1785177 - 1356 WP_021339945.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
AWC34_RS08595 1785190..1786260 - 1071 WP_002507100.1 D-alanine--D-alanine ligase -
AWC34_RS08600 1786535..1787737 + 1203 WP_002507099.1 rod shape-determining protein RodA -
AWC34_RS13580 1787893..1788033 - 141 WP_002507098.1 hypothetical protein -
AWC34_RS08605 1788247..1788459 - 213 WP_031266142.1 heavy-metal-associated domain-containing protein Toxin
AWC34_RS08610 1788474..1788767 - 294 WP_002507096.1 copper-sensing transcriptional repressor CsoR Antitoxin
AWC34_RS08615 1788911..1790395 + 1485 WP_021339943.1 cardiolipin synthase -
AWC34_RS08620 1790523..1791173 + 651 WP_021339942.1 HD domain-containing protein -
AWC34_RS08625 1791244..1792113 - 870 WP_002507093.1 membrane protein insertase YidC -
AWC34_RS08630 1792201..1792839 - 639 WP_021339941.1 thiamine phosphate synthase -
AWC34_RS08635 1792839..1793630 - 792 WP_031266140.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(18-67)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 8116.13 Da        Isoelectric Point: 4.5086

>T59748 WP_031266142.1 NZ_CP013980:c1788459-1788247 [Staphylococcus equorum]
VVTKVIYISGIENETQQKHIEQQLKQLHGVHQVNIEIESNNGKIFIDFETPASLNNLEKEVYDLGYEILY

Download         Length: 213 bp

>T59748 NZ_CP013980:c1788459-1788247 [Staphylococcus equorum]
GTGGTAACAAAAGTTATTTATATTTCCGGTATAGAAAATGAAACACAACAAAAACATATTGAACAGCAGCTTAAGCAATT
ACACGGTGTACACCAAGTCAACATAGAAATAGAAAGCAATAATGGCAAAATTTTCATTGATTTTGAAACCCCTGCAAGTT
TAAATAATTTAGAAAAAGAAGTTTATGATTTAGGATATGAAATTTTATATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11195.87 Da        Isoelectric Point: 6.4791

>AT59748 WP_002507096.1 NZ_CP013980:c1788767-1788474 [Staphylococcus equorum]
MAEIQKAHHSEQIKSNLKSRLNRIEGQVRAINRMVDEDVYCDDVLTQIRATRSALNGVATKLLDHHMKSCIMEKVEQGQQ
EEAMEELLVTFQKLMKD

Download         Length: 294 bp

>AT59748 NZ_CP013980:c1788767-1788474 [Staphylococcus equorum]
ATGGCGGAAATACAAAAAGCGCATCACTCAGAACAAATTAAATCTAATTTAAAATCAAGATTAAATCGTATAGAAGGCCA
AGTGAGAGCAATTAATCGCATGGTAGATGAAGATGTTTATTGTGATGACGTGCTCACACAAATTAGAGCCACTCGATCGG
CTTTAAATGGTGTTGCTACTAAATTATTAGACCATCATATGAAAAGTTGTATTATGGAAAAAGTAGAGCAGGGTCAACAA
GAAGAAGCTATGGAAGAACTATTGGTTACATTTCAAAAATTAATGAAGGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A192F7F2

Antitoxin

Source ID Structure
AlphaFold DB J9GWP4

References