Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-YefM
Location 913714..914225 Replicon chromosome
Accession NZ_CP013979
Organism Agromyces aureus strain AR33

Toxin (Protein)


Gene name relB Uniprot ID A0A191WCK2
Locus tag ATC03_RS03830 Protein ID WP_067873295.1
Coordinates 913959..914225 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A191WKE9
Locus tag ATC03_RS03825 Protein ID WP_067881340.1
Coordinates 913714..913962 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ATC03_RS03815 908985..909317 - 333 WP_067873289.1 PadR family transcriptional regulator -
ATC03_RS20155 909669..910016 + 348 WP_152030859.1 hypothetical protein -
ATC03_RS03820 910128..913379 + 3252 WP_084003270.1 right-handed parallel beta-helix repeat-containing protein -
ATC03_RS03825 913714..913962 + 249 WP_067881340.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
ATC03_RS03830 913959..914225 + 267 WP_067873295.1 Txe/YoeB family addiction module toxin Toxin
ATC03_RS19715 914274..914753 - 480 WP_084003679.1 recombinase family protein -
ATC03_RS03840 914697..914990 + 294 WP_084003271.1 hypothetical protein -
ATC03_RS03845 914977..915621 + 645 WP_067873301.1 CoA transferase subunit B -
ATC03_RS03850 915659..916636 - 978 WP_067873304.1 LLM class flavin-dependent oxidoreductase -
ATC03_RS03855 916759..917418 + 660 WP_067873307.1 pentapeptide repeat-containing protein -
ATC03_RS03860 917524..918423 + 900 WP_067873311.1 methylisocitrate lyase -
ATC03_RS03865 918524..919192 - 669 WP_067873316.1 GAP family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10510.84 Da        Isoelectric Point: 6.4671

>T59741 WP_067873295.1 NZ_CP013979:913959-914225 [Agromyces aureus]
MSDRNLAWSVEGWEDYLYWQTQDRRTLKRINTIIADILRDDPFEGIGKPEPLKHALAGAWSRRIDEANRLVYIADERYVT
VLQARYHY

Download         Length: 267 bp

>T59741 NZ_CP013979:913959-914225 [Agromyces aureus]
TTGAGTGACCGGAACCTGGCGTGGTCTGTCGAAGGCTGGGAGGACTATCTCTATTGGCAGACCCAAGATCGTCGAACACT
CAAGCGGATCAACACGATCATCGCCGACATTCTCCGAGACGACCCCTTCGAGGGCATCGGAAAACCCGAGCCCCTGAAGC
ATGCCCTGGCCGGAGCGTGGTCACGGCGAATCGACGAGGCCAACCGTCTCGTCTACATTGCCGATGAACGGTACGTCACG
GTCCTGCAAGCCCGTTATCACTACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9242.37 Da        Isoelectric Point: 4.4002

>AT59741 WP_067881340.1 NZ_CP013979:913714-913962 [Agromyces aureus]
MAITTSEARRDLFGLIERVNLDQTEVEITSKRGSAVLMSKDEYDSLVETSYLLRSPENARRLLSAMEQARAGDVVEHELL
ES

Download         Length: 249 bp

>AT59741 NZ_CP013979:913714-913962 [Agromyces aureus]
ATGGCTATCACGACAAGCGAAGCGCGCCGCGATCTCTTCGGCCTGATCGAGCGAGTGAACCTCGATCAGACCGAGGTCGA
GATCACGTCGAAGCGGGGCTCCGCAGTGCTCATGTCGAAGGACGAGTACGACTCCCTCGTCGAGACAAGCTATCTCTTGC
GCTCCCCTGAGAACGCGCGGCGGCTCCTCAGCGCCATGGAGCAGGCTCGAGCAGGCGACGTCGTCGAGCACGAACTCCTC
GAGTCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A191WCK2

Antitoxin

Source ID Structure
AlphaFold DB A0A191WKE9

References