Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 52006..52537 Replicon plasmid pPSCRG02-1
Accession NZ_CP013976
Organism Piscirickettsia salmonis strain CGR02

Toxin (Protein)


Gene name relE Uniprot ID A0A7U4YYE1
Locus tag AWJ11_RS16220 Protein ID WP_027243212.1
Coordinates 52250..52537 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1L6TI86
Locus tag AWJ11_RS16215 Protein ID WP_027243211.1
Coordinates 52006..52260 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AWJ11_RS16185 47137..47646 + 510 WP_027242595.1 hypothetical protein -
AWJ11_RS16190 47878..48858 + 981 WP_144420849.1 hypothetical protein -
AWJ11_RS16195 48940..49284 - 345 Protein_64 DDE-type integrase/transposase/recombinase -
AWJ11_RS16200 49324..50301 - 978 WP_036771347.1 IS5 family transposase -
AWJ11_RS16205 50383..50616 + 234 WP_062365770.1 hypothetical protein -
AWJ11_RS16210 50635..51612 + 978 WP_036771347.1 IS5 family transposase -
AWJ11_RS20640 51627..51788 + 162 WP_155046636.1 hypothetical protein -
AWJ11_RS16215 52006..52260 + 255 WP_027243211.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
AWJ11_RS16220 52250..52537 + 288 WP_027243212.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AWJ11_RS16225 52544..53005 - 462 Protein_71 tail assembly protein -
AWJ11_RS16230 53032..54009 - 978 WP_036771347.1 IS5 family transposase -
AWJ11_RS16235 54091..54774 + 684 WP_051929558.1 IS5 family transposase -
AWJ11_RS19955 54802..54954 - 153 WP_155046629.1 hypothetical protein -
AWJ11_RS16240 55356..57095 + 1740 WP_016212146.1 PLD-like domain protein -
AWJ11_RS16245 57098..57460 + 363 WP_082304501.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..115926 115926


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(8-55)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11063.21 Da        Isoelectric Point: 10.8855

>T59738 WP_027243212.1 NZ_CP013976:52250-52537 [Piscirickettsia salmonis]
MTYKLQFHKEAYKEWKKLNPTTQQQFQKVLKKRLINPHIPSAVCGGDLKGCYKIKLRALGYRLIYTVKKDKVVVQVLAIG
SRNRLEAYRLAASRL

Download         Length: 288 bp

>T59738 NZ_CP013976:52250-52537 [Piscirickettsia salmonis]
ATGACTTATAAATTACAATTTCACAAAGAAGCGTATAAAGAGTGGAAAAAACTAAATCCAACAACTCAGCAACAGTTTCA
AAAAGTTTTGAAAAAACGCTTAATTAACCCACATATCCCATCAGCAGTGTGTGGTGGTGATTTAAAAGGCTGCTATAAAA
TTAAATTAAGAGCGCTCGGTTATCGTTTAATTTATACAGTGAAAAAGGACAAAGTGGTTGTTCAAGTCTTGGCCATTGGT
TCCAGAAACCGCTTAGAAGCGTATCGTTTAGCGGCAAGTCGCCTATAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9554.83 Da        Isoelectric Point: 4.3176

>AT59738 WP_027243211.1 NZ_CP013976:52006-52260 [Piscirickettsia salmonis]
MKQLYAQQSVTITELRKSPTSVINEANGEPVVILNHNVPAAYMVPPELFEAMLDSYEDRQLEGIVKKRLHSPDRDFIDVD
VDDL

Download         Length: 255 bp

>AT59738 NZ_CP013976:52006-52260 [Piscirickettsia salmonis]
ATGAAACAGCTCTACGCACAACAGTCGGTAACAATTACAGAACTTAGAAAAAGCCCAACCAGCGTTATCAATGAAGCCAA
CGGCGAACCGGTGGTTATTTTGAATCATAATGTTCCTGCGGCGTACATGGTGCCACCTGAACTTTTTGAAGCCATGCTCG
ACTCGTATGAAGACCGCCAACTTGAAGGCATAGTCAAAAAACGTTTACATTCTCCTGACCGTGACTTTATTGATGTCGAT
GTCGATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4YYE1

Antitoxin

Source ID Structure
AlphaFold DB A0A1L6TI86

References