Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 521650..522413 Replicon chromosome
Accession NZ_CP013975
Organism Piscirickettsia salmonis strain CGR02

Toxin (Protein)


Gene name ataT Uniprot ID A0A1L6TH26
Locus tag AWJ11_RS02585 Protein ID WP_017376502.1
Coordinates 521904..522413 (+) Length 170 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A1L6TGZ1
Locus tag AWJ11_RS02580 Protein ID WP_017376501.1
Coordinates 521650..521916 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AWJ11_RS02555 517289..517876 + 588 Protein_502 IS982-like element ISPsa1 family transposase -
AWJ11_RS17445 518000..519403 + 1404 WP_048876031.1 IS4 family transposase -
AWJ11_RS02565 519417..519713 + 297 Protein_504 transposase -
AWJ11_RS17450 519782..520330 + 549 WP_196480236.1 transposase -
AWJ11_RS02575 520510..521484 + 975 WP_048875903.1 IS30 family transposase -
AWJ11_RS02580 521650..521916 + 267 WP_017376501.1 DUF1778 domain-containing protein Antitoxin
AWJ11_RS02585 521904..522413 + 510 WP_017376502.1 GNAT family N-acetyltransferase Toxin
AWJ11_RS02590 522534..523409 - 876 WP_048875904.1 IS982 family transposase -
AWJ11_RS20135 523603..523908 - 306 WP_146619445.1 transposase -
AWJ11_RS20140 523912..524574 - 663 WP_174872532.1 transposase -
AWJ11_RS17455 524499..524738 - 240 WP_075275277.1 transposase zinc-binding domain-containing protein -
AWJ11_RS02605 525069..525599 - 531 WP_017375999.1 transcriptional repressor -
AWJ11_RS02610 525599..526126 - 528 WP_026063500.1 inorganic diphosphatase -
AWJ11_RS02615 526286..527401 - 1116 WP_017376001.1 DSD1 family PLP-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 517289..523409 6120


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(70-146)

Antitoxin

Vibrio phage ICP1, Orf50

(7-81)


Sequences

Toxin        


Download         Length: 170 a.a.        Molecular weight: 18875.95 Da        Isoelectric Point: 8.6859

>T59735 WP_017376502.1 NZ_CP013975:521904-522413 [Piscirickettsia salmonis]
MGEITPPELLESSHDTRGFDCGDIALNEWLQKRGLKNQTSDASRVYVITNRHRVIGYYALASGSVERMIVPGSIARNMPE
TIPVIVLGRLAVDLDYHDQKLGSGLLKDALIRCMLAADTIAAKAVMVHAISDRAKQFYTKNSFVQCPEIEMTLFISIKKI
RQLLKNETK

Download         Length: 510 bp

>T59735 NZ_CP013975:521904-522413 [Piscirickettsia salmonis]
TTGGGAGAAATAACACCGCCGGAGCTGCTAGAGTCTAGCCATGATACTCGAGGTTTTGATTGCGGAGATATTGCGCTTAA
TGAGTGGTTACAAAAGCGAGGATTAAAAAATCAGACCTCTGATGCAAGTCGAGTGTATGTAATTACTAATCGTCATCGAG
TGATTGGCTATTATGCGTTAGCCAGTGGCTCTGTGGAGCGAATGATCGTACCTGGCTCCATAGCTCGTAATATGCCAGAG
ACAATTCCGGTGATTGTGCTAGGGCGGCTAGCCGTTGACCTTGATTATCACGATCAAAAACTAGGAAGCGGCTTATTAAA
AGATGCTTTAATTCGGTGTATGCTAGCTGCTGATACAATCGCTGCAAAGGCAGTCATGGTTCATGCAATCTCAGATAGAG
CAAAACAGTTTTATACTAAAAACTCTTTTGTCCAATGTCCTGAAATTGAAATGACTTTATTTATTTCTATAAAAAAAATT
AGGCAACTTCTAAAAAATGAAACAAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10033.51 Da        Isoelectric Point: 4.4819

>AT59735 WP_017376501.1 NZ_CP013975:521650-521916 [Piscirickettsia salmonis]
MAKVTPISMRTTAEQFDLLTKAANALNIDRTSFILNIACREAENVLLDRRLFQLNDEAFDAFEAALDEPLTQPEKLKRLL
TEPAPWEK

Download         Length: 267 bp

>AT59735 NZ_CP013975:521650-521916 [Piscirickettsia salmonis]
ATGGCAAAGGTAACACCGATTAGCATGCGTACAACAGCGGAACAGTTTGATTTACTTACTAAAGCAGCAAATGCATTAAA
TATAGACCGCACATCGTTCATTTTGAATATTGCTTGCCGTGAAGCTGAAAACGTACTGCTAGACCGCCGTTTGTTTCAAT
TAAATGATGAAGCTTTTGATGCCTTTGAGGCAGCACTAGATGAGCCATTAACTCAACCAGAGAAATTAAAACGCTTACTA
ACGGAGCCTGCACCTTGGGAGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L6TH26

Antitoxin

Source ID Structure
AlphaFold DB A0A1L6TGZ1

References