Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2402844..2403358 Replicon chromosome
Accession NZ_CP013957
Organism Staphylococcus aureus strain V521 isolate Sequencing

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag ASL17_RS12440 Protein ID WP_000581792.1
Coordinates 2402844..2403053 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag ASL17_RS12445 Protein ID WP_000138932.1
Coordinates 2403065..2403358 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASL17_RS12420 2398332..2399690 - 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
ASL17_RS12425 2399705..2400775 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
ASL17_RS12430 2401093..2402295 + 1203 WP_001109939.1 rod shape-determining protein RodA -
ASL17_RS12435 2402559..2402696 - 138 WP_000828354.1 hypothetical protein -
ASL17_RS12440 2402844..2403053 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
ASL17_RS12445 2403065..2403358 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
ASL17_RS12450 2403524..2405008 + 1485 WP_000571549.1 cardiolipin synthase -
ASL17_RS12455 2405036..2405683 + 648 WP_001187629.1 HD domain-containing protein -
ASL17_RS12470 2406496..2407368 - 873 WP_000725802.1 membrane protein insertase YidC -
ASL17_RS12475 2407454..2408095 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T59721 WP_000581792.1 NZ_CP013957:c2403053-2402844 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T59721 NZ_CP013957:c2403053-2402844 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT59721 WP_000138932.1 NZ_CP013957:c2403358-2403065 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT59721 NZ_CP013957:c2403358-2403065 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References