Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-doc
Location 2262021..2262646 Replicon chromosome
Accession NZ_CP013957
Organism Staphylococcus aureus strain V521 isolate Sequencing

Toxin (Protein)


Gene name doc Uniprot ID A0A380FZ43
Locus tag ASL17_RS11735 Protein ID WP_001179607.1
Coordinates 2262021..2262416 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A380FXS4
Locus tag ASL17_RS11740 Protein ID WP_000258939.1
Coordinates 2262416..2262646 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASL17_RS11695 2257576..2258016 - 441 Protein_2236 GNAT family N-acetyltransferase -
ASL17_RS11700 2257991..2258242 - 252 WP_002505594.1 hypothetical protein -
ASL17_RS11705 2258239..2258874 - 636 Protein_2238 aminoglycoside 6-adenylyltransferase -
ASL17_RS11710 2259089..2259811 - 723 WP_001043218.1 hypothetical protein -
ASL17_RS11715 2259920..2260720 - 801 WP_000686449.1 metallophosphoesterase -
ASL17_RS11720 2260724..2261218 - 495 WP_000280790.1 hypothetical protein -
ASL17_RS11725 2261275..2261544 - 270 WP_000755772.1 hypothetical protein -
ASL17_RS11730 2261528..2261719 - 192 WP_032605691.1 hypothetical protein -
ASL17_RS11735 2262021..2262416 - 396 WP_001179607.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
ASL17_RS11740 2262416..2262646 - 231 WP_000258939.1 addiction module antitoxin Antitoxin
ASL17_RS11745 2262822..2263343 - 522 WP_000639078.1 metallophosphoesterase -
ASL17_RS11750 2263343..2263993 - 651 WP_000411528.1 hypothetical protein -
ASL17_RS11755 2263993..2264310 - 318 WP_001807410.1 hypothetical protein -
ASL17_RS11760 2264303..2265028 - 726 WP_000197304.1 metallophosphoesterase -
ASL17_RS11765 2265028..2265249 - 222 WP_000829423.1 hypothetical protein -
ASL17_RS17210 2265269..2265454 - 186 WP_129760514.1 hypothetical protein -
ASL17_RS11770 2265438..2265980 - 543 WP_000858632.1 hypothetical protein -
ASL17_RS11775 2265995..2266267 - 273 WP_000691100.1 hypothetical protein -
ASL17_RS11780 2266293..2266448 - 156 WP_000792995.1 transcriptional regulator -
ASL17_RS17215 2266562..2266729 - 168 WP_000312832.1 hypothetical protein -
ASL17_RS11785 2266745..2266930 - 186 WP_001187008.1 hypothetical protein -
ASL17_RS11790 2266915..2267094 - 180 WP_000401832.1 hypothetical protein -
ASL17_RS11795 2267108..2267590 - 483 WP_000833764.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage aac(6')-aph(2'') / aph(3')-III - 2224234..2354780 130546


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 15035.51 Da        Isoelectric Point: 9.4574

>T59719 WP_001179607.1 NZ_CP013957:c2262416-2262021 [Staphylococcus aureus]
MQNIKYLTEKQVIAINVKAIQELSPKEQVGVKVPEVLNATIEGVKQSFGGVELYETIERKAAFIYRNIAQKHAFFNANKR
TAFTSMVIFLKLNKINFNCTQDEAVQFTLKVVEDKTLTLEDIADWIKRHCK

Download         Length: 396 bp

>T59719 NZ_CP013957:c2262416-2262021 [Staphylococcus aureus]
ATGCAAAACATTAAATATTTAACTGAAAAACAAGTAATTGCCATTAATGTAAAAGCAATTCAAGAACTCTCACCTAAAGA
ACAAGTTGGTGTTAAAGTTCCAGAGGTTCTTAATGCTACTATTGAAGGAGTTAAACAATCATTTGGTGGAGTTGAACTAT
ATGAAACAATCGAGAGAAAAGCGGCTTTTATATACAGAAATATAGCTCAAAAACATGCATTCTTTAATGCGAATAAGAGA
ACAGCTTTTACATCTATGGTTATTTTCTTGAAGTTAAATAAGATTAATTTTAATTGTACTCAAGACGAAGCGGTACAATT
TACTTTAAAAGTGGTAGAGGATAAAACTCTTACACTTGAAGATATTGCAGATTGGATCAAAAGGCATTGTAAATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8617.73 Da        Isoelectric Point: 4.4501

>AT59719 WP_000258939.1 NZ_CP013957:c2262646-2262416 [Staphylococcus aureus]
MVTTRKLRRAGNSSVVSVPTEVIAALGVTNGDNLKFNIEDNKVTIEKEVNEDEEFFKLLDETFTEYNQALRKLVDI

Download         Length: 231 bp

>AT59719 NZ_CP013957:c2262646-2262416 [Staphylococcus aureus]
ATGGTTACTACAAGAAAACTAAGAAGAGCTGGCAATAGTTCAGTTGTTTCTGTACCAACAGAAGTGATCGCAGCACTCGG
AGTTACAAATGGTGACAATCTTAAATTTAATATTGAAGATAATAAAGTAACCATTGAAAAGGAGGTAAACGAAGACGAAG
AGTTTTTCAAATTGTTGGATGAAACATTCACTGAGTATAACCAAGCTCTGAGAAAGTTGGTTGACATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380FZ43

Antitoxin

Source ID Structure
AlphaFold DB A0A380FXS4

References