Detailed information of TA system TA059714

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /HTH_19(antitoxin)
• Location: 2082804..2083595
• Replicon: chromosome
• Accession: NZ_CP013957
• Organism: Staphylococcus aureus strain V521 isolate Sequencing

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: ASL17_RS10610
• Protein ID: WP_000525003.1
• Coordinates: 2083131..2083595 (+)
• Length: 155 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A0E7YIA0
• Locus tag: ASL17_RS10605
• Protein ID: WP_000333630.1
• Coordinates: 2082804..2083118 (+)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ASL17_RS10555	2079054..2079317	-	264	WP_001205732.1	hypothetical protein	-
ASL17_RS10560	2079326..2079586	-	261	WP_031825655.1	DUF1108 family protein	-
ASL17_RS10565	2079611..2079892	-	282	WP_063655725.1	DUF2482 family protein	-
ASL17_RS10570	2079986..2080147	-	162	WP_000048130.1	DUF1270 family protein	-
ASL17_RS10575	2080140..2080361	-	222	WP_000594790.1	hypothetical protein	-
ASL17_RS10580	2080432..2080662	+	231	WP_000395455.1	hypothetical protein	-
ASL17_RS10585	2080838..2081581	-	744	WP_001148594.1	phage antirepressor KilAC domain-containing protein	-
ASL17_RS10590	2081641..2082123	+	483	WP_000394410.1	hypothetical protein	-
ASL17_RS10595	2082224..2082403	-	180	WP_000438352.1	hypothetical protein	-
ASL17_RS10600	2082422..2082652	-	231	WP_103263741.1	helix-turn-helix domain-containing protein	-
ASL17_RS10605	2082804..2083118	+	315	WP_000333630.1	helix-turn-helix domain-containing protein	Antitoxin
ASL17_RS10610	2083131..2083595	+	465	WP_000525003.1	hypothetical protein	Toxin
ASL17_RS10615	2083627..2084559	+	933	WP_031837133.1	hypothetical protein	-
ASL17_RS10620	2084539..2084718	-	180	WP_000337827.1	hypothetical protein	-
ASL17_RS10625	2084831..2085877	+	1047	WP_001145722.1	site-specific integrase	-
ASL17_RS10630	2085922..2087067	+	1146	WP_001245441.1	radical SAM/CxCxxxxC motif protein YfkAB	-
ASL17_RS10635	2087327..2087857	-	531	WP_000184383.1	acyl-CoA thioesterase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2041550..2085877	44327

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (4-62)

Sequences

Toxin

Protein

• Length: 155 a.a.
• Molecular weight: 18156.52 Da
• Isoelectric Point: 4.7927

>T59714 WP_000525003.1 NZ_CP013957:2083131-2083595 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKLHHID

Nucleotide

• Length: 465 bp

>T59714 NZ_CP013957:2083131-2083595 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTGATAAAGCGTGGTTTATCAGATAGAGAAAAGGCAGGGATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGA
CGACACGGCTTTATCTCAGCTGTTCCATTACGCGAAATTGTAGAAGCTTATAATTATGGCGTACGTAACTTGTATGAATT
GTCTGAGTATCTACAATTAAGCGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGAACTC
ACTATGGCGAGTATTCGATCACATTTGAGCCGTTGAGAGTTTTTAAATTGCATCACATTGATTAA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 12063.56 Da
• Isoelectric Point: 6.4736

>AT59714 WP_000333630.1 NZ_CP013957:2082804-2083118 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Nucleotide

• Length: 315 bp

>AT59714 NZ_CP013957:2082804-2083118 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAACGTTATGAAAGCGGAAATATCAAAAATCTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCGTATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCATCTT
GAAGGAGAATTGACAGATGACGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0E7YIA0