Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 957563..958068 Replicon chromosome
Accession NZ_CP013957
Organism Staphylococcus aureus strain V521 isolate Sequencing

Toxin (Protein)


Gene name TscT Uniprot ID A0A0C6E6D5
Locus tag ASL17_RS04830 Protein ID WP_001103946.1
Coordinates 957775..958068 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID X5IA75
Locus tag ASL17_RS04825 Protein ID WP_001058492.1
Coordinates 957563..957772 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASL17_RS04790 953079..954299 - 1221 WP_000264182.1 site-specific integrase -
ASL17_RS04795 954387..955115 - 729 WP_000733773.1 staphylococcal enterotoxin type K -
ASL17_RS04800 955139..955867 - 729 WP_001033317.1 staphylococcal enterotoxin type Q -
ASL17_RS04805 956042..956777 - 736 Protein_923 helix-turn-helix transcriptional regulator -
ASL17_RS04810 956927..957139 + 213 WP_001063624.1 helix-turn-helix transcriptional regulator -
ASL17_RS04815 957140..957412 + 273 WP_001138298.1 helix-turn-helix domain-containing protein -
ASL17_RS04820 957424..957570 + 147 WP_000784885.1 hypothetical protein -
ASL17_RS04825 957563..957772 + 210 WP_001058492.1 hypothetical protein Antitoxin
ASL17_RS04830 957775..958068 + 294 WP_001103946.1 DUF1474 family protein Toxin
ASL17_RS04835 958156..959025 + 870 WP_001002691.1 primase alpha helix C-terminal domain-containing protein -
ASL17_RS04840 959042..960499 + 1458 WP_000432707.1 virulence-associated E family protein -
ASL17_RS04845 960801..961163 + 363 WP_001039172.1 hypothetical protein -
ASL17_RS04850 961165..961449 + 285 WP_000998180.1 hypothetical protein -
ASL17_RS04855 961446..962087 + 642 WP_001019783.1 hypothetical protein -
ASL17_RS04860 962536..962877 + 342 WP_001190616.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selk / selq 935128..965191 30063


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-97)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11590.08 Da        Isoelectric Point: 4.9594

>T59710 WP_001103946.1 NZ_CP013957:957775-958068 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASLQADQSESNA

Download         Length: 294 bp

>T59710 NZ_CP013957:957775-958068 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAAGTGTACTTAAAAGAGTTCGGTGAACTTATACAAAAGTTT
CATGAAATAGAAAAAGCGTCACTTCAAGCCGATCAAAGCGAAAGTAACGCATAG

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8238.28 Da        Isoelectric Point: 4.3718

>AT59710 WP_001058492.1 NZ_CP013957:957563-957772 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT59710 NZ_CP013957:957563-957772 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C6E6D5

Antitoxin

Source ID Structure
AlphaFold DB X5IA75

References