Detailed information of TA system TA059701

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 2176079..2176557
• Replicon: chromosome
• Accession: NZ_CP013955
• Organism: Staphylococcus aureus strain NCCP14562 isolate Sequencing

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: A0A0H3K0C1
• Locus tag: ASL15_RS10960
• Protein ID: WP_001078344.1
• Coordinates: 2176079..2176405 (-)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: ASL15_RS10965
• Protein ID: WP_025175789.1
• Coordinates: 2176408..2176557 (-)
• Length: 50 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ASL15_RS10935	2171303..2171644	-	342	WP_001190615.1	hypothetical protein	-
ASL15_RS10940	2172094..2172735	-	642	WP_063663566.1	pathogenicity island protein	-
ASL15_RS10945	2172732..2173112	-	381	WP_000356942.1	hypothetical protein	-
ASL15_RS10950	2173422..2175131	-	1710	WP_000447473.1	DUF927 domain-containing protein	-
ASL15_RS10955	2175145..2176014	-	870	WP_001002689.1	primase alpha helix C-terminal domain-containing protein	-
ASL15_RS10960	2176079..2176405	-	327	WP_001078344.1	DUF1474 family protein	Toxin
ASL15_RS10965	2176408..2176557	-	150	WP_025175789.1	hypothetical protein	Antitoxin
ASL15_RS10970	2176610..2176756	-	147	WP_000784885.1	hypothetical protein	-
ASL15_RS10975	2176753..2177070	-	318	WP_000481967.1	helix-turn-helix domain-containing protein	-
ASL15_RS10980	2177075..2177293	-	219	WP_000153640.1	helix-turn-helix transcriptional regulator	-
ASL15_RS10985	2177466..2178140	+	675	WP_000620857.1	helix-turn-helix transcriptional regulator	-
ASL15_RS10990	2178154..2179326	+	1173	WP_000179343.1	site-specific integrase	-
ASL15_RS10995	2179395..2181011	-	1617	WP_000240642.1	chaperonin GroEL	-
ASL15_RS11000	2181087..2181371	-	285	WP_000917289.1	co-chaperone GroES	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sell / sec / tsst-1 / groEL	2155028..2184384	29356

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-100)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 12968.26 Da
• Isoelectric Point: 4.3050

>T59701 WP_001078344.1 NZ_CP013955:c2176405-2176079 [Staphylococcus aureus]
MNREIKDLFSDLKLLKDSFEDLKDSNGWHFDELYPYEPNHVLNKDELIGEGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFYEIEKASSENFGEESDDAKNSIKVAE

Nucleotide

• Length: 327 bp

>T59701 NZ_CP013955:c2176405-2176079 [Staphylococcus aureus]
ATGAATCGGGAAATTAAAGATTTATTTAGCGATTTAAAGTTGTTGAAAGATAGTTTTGAGGATTTAAAGGATAGTAATGG
TTGGCATTTTGATGAGCTATATCCATATGAACCAAATCATGTCTTAAATAAAGATGAATTAATTGGAGAGGGATTTTCTT
ATCATGAGAGACGTATTCACAATAATCAAATGTTTGATTTATTCCATCTCTATATAGAGCAGTTCGATAATATTATCGAA
AAGTTTTATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGC
AGAGTAA

Antitoxin

Protein

• Length: 50 a.a.
• Molecular weight: 5822.52 Da
• Isoelectric Point: 4.4876

>AT59701 WP_025175789.1 NZ_CP013955:c2176557-2176408 [Staphylococcus aureus]
VNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 150 bp

>AT59701 NZ_CP013955:c2176557-2176408 [Staphylococcus aureus]
GTGAATAATTTGGAAAGTTATGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCA
CTTAGAATTGATAATGAAATGGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Toxin

• AlphaFold DB: A0A0H3K0C1