Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) tsbAT/-
Location 2053840..2054616 Replicon chromosome
Accession NZ_CP013955
Organism Staphylococcus aureus strain NCCP14562 isolate Sequencing

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag ASL15_RS10215 Protein ID WP_000031108.1
Coordinates 2053840..2053992 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag ASL15_RS10220 Protein ID WP_001251224.1
Coordinates 2054017..2054616 (-) Length 200 a.a.

Genomic Context


ASL15_RS10200ASL15_RS10205ASL15_RS10210ASL15_RS10215ASL15_RS10220ASL15_RS10225ASL15_RS10230ASL15_RS10235ASL15_RS10240
Location: 2050042..2050863 (822 bp)
Type: Others
Protein ID: WP_000669376.1
Location: 2051316..2052701 (1386 bp)
Type: Others
Protein ID: WP_000116228.1
Location: 2052897..2053292 (396 bp)
Type: Others
Protein ID: WP_000901023.1
Location: 2053840..2053992 (153 bp)
Type: Toxin
Protein ID: WP_000031108.1
Location: 2054017..2054616 (600 bp)
Type: Antitoxin
Protein ID: WP_001251224.1
Location: 2054775..2055245 (471 bp)
Type: Others
Protein ID: WP_000181394.1
Location: 2055250..2056377 (1128 bp)
Type: Others
Protein ID: WP_000379980.1
Location: 2056528..2057250 (723 bp)
Type: Others
Protein ID: WP_000590809.1
Location: 2057243..2058700 (1458 bp)
Type: Others
Protein ID: WP_000649908.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASL15_RS102002050042..2050863+822WP_000669376.1RluA family pseudouridine synthase-
ASL15_RS102052051316..2052701-1386WP_000116228.1class II fumarate hydratase-
ASL15_RS102102052897..2053292-396WP_000901023.1hypothetical protein-
ASL15_RS102152053840..2053992-153WP_000031108.1hypothetical proteinToxin
ASL15_RS102202054017..2054616-600WP_001251224.1glucosamine-6-phosphate isomeraseAntitoxin
ASL15_RS102252054775..2055245-471WP_000181394.1tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL-
ASL15_RS102302055250..2056377-1128WP_000379980.1tRNA epoxyqueuosine(34) reductase QueG-
ASL15_RS102352056528..2057250-723WP_000590809.1amino acid ABC transporter ATP-binding protein-
ASL15_RS102402057243..2058700-1458WP_000649908.1ABC transporter permease subunit-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(124-196)


Sequences


Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T59700 WP_000031108.1 NZ_CP013955:c2053992-2053840 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T59700 NZ_CP013955:c2053992-2053840 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAAAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT59700 WP_001251224.1 NZ_CP013955:c2054616-2054017 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT59700 NZ_CP013955:c2054616-2054017 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBX5E2E6


Antitoxin

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Source
ID
Structure
AlphaFold DBW8U4V4

References