59694

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 914019..914496 Replicon chromosome
Accession NZ_CP013955
Organism Staphylococcus aureus strain NCCP14562 isolate Sequencing

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag ASL15_RS04420 Protein ID WP_000052076.1
Coordinates 914019..914207 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag ASL15_RS04425 Protein ID WP_001059690.1
Coordinates 914236..914496 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASL15_RS04390 910013..910534 + 522 WP_000824482.1 hypothetical protein -
ASL15_RS04395 910875..911561 + 687 WP_000141557.1 thermonuclease family protein -
ASL15_RS04400 911918..912118 + 201 WP_001059082.1 cold-shock protein -
ASL15_RS04405 912610..912828 - 219 WP_000005886.1 hypothetical protein -
ASL15_RS04410 912890..913174 - 285 WP_001004399.1 hypothetical protein -
ASL15_RS04415 913262..913831 - 570 WP_001106654.1 hypothetical protein -
ASL15_RS04420 914019..914207 - 189 WP_000052076.1 hypothetical protein Toxin
ASL15_RS04425 914236..914496 - 261 WP_001059690.1 hypothetical protein Antitoxin
ASL15_RS04430 914837..915040 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
ASL15_RS04435 915037..915273 - 237 WP_000349581.1 hypothetical protein -
ASL15_RS04440 915498..916079 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
ASL15_RS04445 916152..916769 - 618 WP_063663419.1 LysE/ArgO family amino acid transporter -
ASL15_RS04450 916924..917418 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
ASL15_RS04455 917817..918239 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
ASL15_RS04460 918387..919103 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T59694 WP_000052076.1 NZ_CP013955:c914207-914019 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T59694 NZ_CP013955:c914207-914019 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT59694 WP_001059690.1 NZ_CP013955:c914496-914236 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT59694 NZ_CP013955:c914496-914236 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References