Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 886101..886630 Replicon chromosome
Accession NZ_CP013955
Organism Staphylococcus aureus strain NCCP14562 isolate Sequencing

Toxin (Protein)


Gene name TscT Uniprot ID K7ZRX2
Locus tag ASL15_RS04255 Protein ID WP_001103933.1
Coordinates 886313..886630 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID A0A6B0BJC0
Locus tag ASL15_RS04250 Protein ID WP_001058487.1
Coordinates 886101..886310 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASL15_RS04215 882552..883016 + 465 WP_001085183.1 SsrA-binding protein SmpB -
ASL15_RS04225 883579..884685 - 1107 WP_000121223.1 site-specific integrase -
ASL15_RS04230 884691..885338 - 648 WP_072474260.1 helix-turn-helix domain-containing protein -
ASL15_RS04235 885496..885702 + 207 WP_001060953.1 hypothetical protein -
ASL15_RS04240 885738..885965 + 228 WP_000164237.1 helix-turn-helix domain-containing protein -
ASL15_RS04245 885962..886108 + 147 WP_000784893.1 hypothetical protein -
ASL15_RS04250 886101..886310 + 210 WP_001058487.1 hypothetical protein Antitoxin
ASL15_RS04255 886313..886630 + 318 WP_001103933.1 DUF1474 family protein Toxin
ASL15_RS04260 886697..887566 + 870 WP_001002695.1 primase alpha helix C-terminal domain-containing protein -
ASL15_RS04265 887583..889052 + 1470 WP_001668899.1 virulence-associated E family protein -
ASL15_RS04270 889338..889700 + 363 WP_001039169.1 hypothetical protein -
ASL15_RS04275 889702..889986 + 285 WP_000998179.1 hypothetical protein -
ASL15_RS04280 889983..890624 + 642 WP_063663413.1 pathogenicity island protein -
ASL15_RS04285 891074..891415 + 342 WP_001190615.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 880158..895393 15235


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12511.13 Da        Isoelectric Point: 4.6364

>T59693 WP_001103933.1 NZ_CP013955:886313-886630 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKEKINDVAIKHGWFVEDKFVKNELETKQEHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASSENFGEESDDAKKLKITE

Download         Length: 318 bp

>T59693 NZ_CP013955:886313-886630 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTGATGTGTGATATTGAAGTGATAAAAGAAAAAATCAATGATGTAGCTATCAAACATGG
TTGGTTTGTTGAAGATAAATTTGTCAAAAATGAATTAGAAACAAAACAGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAGGTGTACTTAAAAGAATTCGGTGAACTTATACAAAAGTTT
CATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCAAAGAAATTAAAAATTACAGAGTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8228.24 Da        Isoelectric Point: 4.1682

>AT59693 WP_001058487.1 NZ_CP013955:886101-886310 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSIMNNFESYEHTEYVDGIEVVSEISPEKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT59693 NZ_CP013955:886101-886310 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTATCATGAATAATTTTGAAAGTTA
TGAACACACGGAATATGTTGATGGTATTGAAGTGGTTTCAGAGATCAGTCCTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAAAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K7ZRX2

Antitoxin

Source ID Structure
AlphaFold DB A0A6B0BJC0

References