Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | TscAT/- |
Location | 2215367..2215845 | Replicon | chromosome |
Accession | NZ_CP013953 | ||
Organism | Staphylococcus aureus strain NCCP14558 isolate sequencing |
Toxin (Protein)
Gene name | TscT | Uniprot ID | A0A0H3K0C1 |
Locus tag | ASL16_RS11300 | Protein ID | WP_001078344.1 |
Coordinates | 2215367..2215693 (-) | Length | 109 a.a. |
Antitoxin (Protein)
Gene name | TscA | Uniprot ID | - |
Locus tag | ASL16_RS11305 | Protein ID | WP_025175789.1 |
Coordinates | 2215696..2215845 (-) | Length | 50 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
ASL16_RS11275 | 2210591..2210932 | - | 342 | WP_001190615.1 | hypothetical protein | - |
ASL16_RS11280 | 2211382..2212023 | - | 642 | WP_063663566.1 | pathogenicity island protein | - |
ASL16_RS11285 | 2212020..2212400 | - | 381 | WP_000356942.1 | hypothetical protein | - |
ASL16_RS11290 | 2212710..2214419 | - | 1710 | WP_000447473.1 | DUF927 domain-containing protein | - |
ASL16_RS11295 | 2214433..2215302 | - | 870 | WP_001002689.1 | primase alpha helix C-terminal domain-containing protein | - |
ASL16_RS11300 | 2215367..2215693 | - | 327 | WP_001078344.1 | DUF1474 family protein | Toxin |
ASL16_RS11305 | 2215696..2215845 | - | 150 | WP_025175789.1 | hypothetical protein | Antitoxin |
ASL16_RS11310 | 2215898..2216044 | - | 147 | WP_000784885.1 | hypothetical protein | - |
ASL16_RS11315 | 2216041..2216358 | - | 318 | WP_000481967.1 | helix-turn-helix domain-containing protein | - |
ASL16_RS11320 | 2216363..2216581 | - | 219 | WP_000153640.1 | helix-turn-helix transcriptional regulator | - |
ASL16_RS11325 | 2216754..2217428 | + | 675 | WP_000620857.1 | helix-turn-helix transcriptional regulator | - |
ASL16_RS11330 | 2217442..2218614 | + | 1173 | WP_000179343.1 | site-specific integrase | - |
ASL16_RS11335 | 2218683..2220299 | - | 1617 | WP_000240642.1 | chaperonin GroEL | - |
ASL16_RS11340 | 2220375..2220659 | - | 285 | WP_000917289.1 | co-chaperone GroES | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | sell / sec / tsst-1 / groEL | 2195649..2223561 | 27912 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 109 a.a. Molecular weight: 12968.26 Da Isoelectric Point: 4.3050
>T59683 WP_001078344.1 NZ_CP013953:c2215693-2215367 [Staphylococcus aureus]
MNREIKDLFSDLKLLKDSFEDLKDSNGWHFDELYPYEPNHVLNKDELIGEGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFYEIEKASSENFGEESDDAKNSIKVAE
MNREIKDLFSDLKLLKDSFEDLKDSNGWHFDELYPYEPNHVLNKDELIGEGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFYEIEKASSENFGEESDDAKNSIKVAE
Download Length: 327 bp
>T59683 NZ_CP013953:c2215693-2215367 [Staphylococcus aureus]
ATGAATCGGGAAATTAAAGATTTATTTAGCGATTTAAAGTTGTTGAAAGATAGTTTTGAGGATTTAAAGGATAGTAATGG
TTGGCATTTTGATGAGCTATATCCATATGAACCAAATCATGTCTTAAATAAAGATGAATTAATTGGAGAGGGATTTTCTT
ATCATGAGAGACGTATTCACAATAATCAAATGTTTGATTTATTCCATCTCTATATAGAGCAGTTCGATAATATTATCGAA
AAGTTTTATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGC
AGAGTAA
ATGAATCGGGAAATTAAAGATTTATTTAGCGATTTAAAGTTGTTGAAAGATAGTTTTGAGGATTTAAAGGATAGTAATGG
TTGGCATTTTGATGAGCTATATCCATATGAACCAAATCATGTCTTAAATAAAGATGAATTAATTGGAGAGGGATTTTCTT
ATCATGAGAGACGTATTCACAATAATCAAATGTTTGATTTATTCCATCTCTATATAGAGCAGTTCGATAATATTATCGAA
AAGTTTTATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGC
AGAGTAA
Antitoxin
Download Length: 50 a.a. Molecular weight: 5822.52 Da Isoelectric Point: 4.4876
>AT59683 WP_025175789.1 NZ_CP013953:c2215845-2215696 [Staphylococcus aureus]
VNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE
VNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE
Download Length: 150 bp
>AT59683 NZ_CP013953:c2215845-2215696 [Staphylococcus aureus]
GTGAATAATTTGGAAAGTTATGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCA
CTTAGAATTGATAATGAAATGGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA
GTGAATAATTTGGAAAGTTATGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCA
CTTAGAATTGATAATGAAATGGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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