Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 908004..908481 Replicon chromosome
Accession NZ_CP013953
Organism Staphylococcus aureus strain NCCP14558 isolate sequencing

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag ASL16_RS04410 Protein ID WP_000052076.1
Coordinates 908004..908192 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag ASL16_RS04415 Protein ID WP_001059690.1
Coordinates 908221..908481 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASL16_RS04380 903528..904214 + 687 WP_000141557.1 thermonuclease family protein -
ASL16_RS04385 904389..905561 - 1173 WP_000195429.1 IS256-like element IS256 family transposase -
ASL16_RS04390 905903..906103 + 201 WP_001059082.1 cold-shock protein -
ASL16_RS04395 906595..906813 - 219 WP_000005886.1 hypothetical protein -
ASL16_RS04400 906875..907159 - 285 WP_001004399.1 hypothetical protein -
ASL16_RS04405 907247..907816 - 570 WP_001106654.1 hypothetical protein -
ASL16_RS04410 908004..908192 - 189 WP_000052076.1 hypothetical protein Toxin
ASL16_RS04415 908221..908481 - 261 WP_001059690.1 hypothetical protein Antitoxin
ASL16_RS04420 908822..909025 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
ASL16_RS04425 909022..909258 - 237 WP_000349581.1 hypothetical protein -
ASL16_RS04430 909483..910064 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
ASL16_RS04435 910137..910754 - 618 WP_063663419.1 LysE/ArgO family amino acid transporter -
ASL16_RS04440 910909..911403 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
ASL16_RS04445 911802..912224 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
ASL16_RS04450 912372..913088 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 904389..905561 1172


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(27-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T59675 WP_000052076.1 NZ_CP013953:c908192-908004 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T59675 NZ_CP013953:c908192-908004 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT59675 WP_001059690.1 NZ_CP013953:c908481-908221 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT59675 NZ_CP013953:c908481-908221 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References