Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3808292..3809123 Replicon chromosome
Accession NZ_CP013952
Organism Escherichia coli strain HST04

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag AWH44_RS19515 Protein ID WP_000854814.1
Coordinates 3808292..3808666 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID P76364
Locus tag AWH44_RS19520 Protein ID WP_001285584.1
Coordinates 3808755..3809123 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AWH44_RS19480 3803688..3804854 + 1167 WP_000830156.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
AWH44_RS19485 3804973..3805446 + 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
AWH44_RS19490 3805644..3806702 + 1059 WP_001200891.1 FUSC family protein -
AWH44_RS19495 3806874..3807203 + 330 WP_000450409.1 DUF496 family protein -
AWH44_RS19500 3807304..3807486 - 183 WP_001016348.1 hypothetical protein -
AWH44_RS19505 3807558..3807686 + 129 Protein_3542 transposase domain-containing protein -
AWH44_RS24110 3807975..3808088 - 114 WP_001161660.1 DUF957 domain-containing protein -
AWH44_RS19510 3808101..3808295 - 195 WP_000988600.1 hypothetical protein -
AWH44_RS19515 3808292..3808666 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
AWH44_RS19520 3808755..3809123 - 369 WP_001285584.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
AWH44_RS19525 3809197..3809418 - 222 WP_000692323.1 DUF987 domain-containing protein -
AWH44_RS19530 3809481..3809927 - 447 WP_000187523.1 RadC family protein -
AWH44_RS19535 3809924..3811456 - 1533 WP_001350525.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T59662 WP_000854814.1 NZ_CP013952:c3808666-3808292 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T59662 NZ_CP013952:c3808666-3808292 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13651.52 Da        Isoelectric Point: 5.9541

>AT59662 WP_001285584.1 NZ_CP013952:c3809123-3808755 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCDYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT59662 NZ_CP013952:c3809123-3808755 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
PDB 2H28
AlphaFold DB A0A1M2E8G6

References