Detailed information of TA system TA059637

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1216..1750
• Replicon: plasmid pPsCRG01-1
• Accession: NZ_CP013946
• Organism: Piscirickettsia salmonis strain PSCGR01

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: AWE47_RS16050
• Protein ID: WP_048876199.1
• Coordinates: 1460..1750 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1L6TI86
• Locus tag: AWE47_RS16045
• Protein ID: WP_027243211.1
• Coordinates: 1216..1470 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AWE47_RS20415	837..998	+	162	WP_155046636.1	hypothetical protein	-
AWE47_RS16045	1216..1470	+	255	WP_027243211.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
AWE47_RS16050	1460..1750	+	291	WP_048876199.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AWE47_RS16055	1737..2714	-	978	WP_036771347.1	IS5 family transposase	-
AWE47_RS16060	3047..3541	-	495	Protein_5	hypothetical protein	-
AWE47_RS20420	3510..3626	-	117	Protein_6	phage minor tail protein L	-
AWE47_RS16065	3715..3927	+	213	WP_053093683.1	hypothetical protein	-
AWE47_RS16070	4085..5062	+	978	WP_036771347.1	IS5 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..179831	179831

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-78)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (8-55)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11119.33 Da
• Isoelectric Point: 10.5762

>T59637 WP_048876199.1 NZ_CP013946:1460-1750 [Piscirickettsia salmonis]
MTYKLQFHKEAYKEWKKLNPTTQQQFQKVLKKRLINPHIPSAVCGGDLKGCYKIKLRALGYRLIYTVKKDKVVVQVLARR
CCVTSGPIFQAQFSCV

Nucleotide

• Length: 291 bp

>T59637 NZ_CP013946:1460-1750 [Piscirickettsia salmonis]
ATGACTTATAAATTACAATTTCACAAAGAAGCGTATAAAGAGTGGAAAAAACTAAATCCAACAACTCAGCAACAGTTTCA
AAAAGTTTTGAAAAAACGCTTAATTAACCCACATATCCCATCAGCAGTGTGTGGTGGTGATTTAAAAGGCTGCTATAAAA
TTAAATTAAGAGCGCTCGGTTATCGTTTAATTTATACAGTGAAAAAGGACAAAGTGGTTGTTCAAGTCTTGGCCAGGCGT
TGTTGCGTAACCTCTGGTCCCATATTCCAGGCACAATTCAGCTGCGTCTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9554.83 Da
• Isoelectric Point: 4.3176

>AT59637 WP_027243211.1 NZ_CP013946:1216-1470 [Piscirickettsia salmonis]
MKQLYAQQSVTITELRKSPTSVINEANGEPVVILNHNVPAAYMVPPELFEAMLDSYEDRQLEGIVKKRLHSPDRDFIDVD
VDDL

Nucleotide

• Length: 255 bp

>AT59637 NZ_CP013946:1216-1470 [Piscirickettsia salmonis]
ATGAAACAGCTCTACGCACAACAGTCGGTAACAATTACAGAACTTAGAAAAAGCCCAACCAGCGTTATCAATGAAGCCAA
CGGCGAACCGGTGGTTATTTTGAATCATAATGTTCCTGCGGCGTACATGGTGCCACCTGAACTTTTTGAAGCCATGCTCG
ACTCGTATGAAGACCGCCAACTTGAAGGCATAGTCAAAAAACGTTTACATTCTCCTGACCGTGACTTTATTGATGTCGAT
GTCGATGACTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A1L6TI86