Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1851461..1851970 Replicon chromosome
Accession NZ_CP013943
Organism Staphylococcus epidermidis strain DAR1907

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag SE1UMMC_RS09445 Protein ID WP_001829980.1
Coordinates 1851461..1851670 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag SE1UMMC_RS09450 Protein ID WP_001829893.1
Coordinates 1851677..1851970 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SE1UMMC_RS09425 1847039..1848394 - 1356 WP_001832734.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
SE1UMMC_RS09430 1848406..1849479 - 1074 WP_001832735.1 D-alanine--D-alanine ligase -
SE1UMMC_RS09435 1849870..1851081 + 1212 WP_001829910.1 rod shape-determining protein RodA -
SE1UMMC_RS09440 1851181..1851318 - 138 WP_001829949.1 hypothetical protein -
SE1UMMC_RS09445 1851461..1851670 - 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
SE1UMMC_RS09450 1851677..1851970 - 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
SE1UMMC_RS09455 1852144..1853628 + 1485 WP_101750562.1 cardiolipin synthase -
SE1UMMC_RS09460 1853810..1854463 + 654 WP_001829983.1 HD domain-containing protein -
SE1UMMC_RS09465 1854569..1855441 - 873 WP_002458703.1 membrane protein insertase YidC -
SE1UMMC_RS09470 1855530..1856168 - 639 WP_002505076.1 thiamine phosphate synthase -
SE1UMMC_RS09475 1856174..1856962 - 789 WP_101750563.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T59634 WP_001829980.1 NZ_CP013943:c1851670-1851461 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T59634 NZ_CP013943:c1851670-1851461 [Staphylococcus epidermidis]
ATGAAATTGAAAAAAGGATTGATAAATGTTTCAGGTATTAAAACAACTGAACAAGCTAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTAGAATTTGACACTCCTGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTACGGATTTCGTATTTTGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT59634 WP_001829893.1 NZ_CP013943:c1851970-1851677 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT59634 NZ_CP013943:c1851970-1851677 [Staphylococcus epidermidis]
ATGGCAGACATGGAGAGTGCACATCACTCAGAGCAAATAAAAACAAATTTAAAATCAAGATTAAATAGAATAGAAGGTCA
AGTAAGAGCAATAAATCGTATGATTGATGATGACGTTTACTGTGATGATGTACTAACTCAAATTAGAGCAACACGTTCAG
CATTGAATAGTGTAGCTACTAAATTACTAGACCATCACATGAAAGGTTGTATTATGGAAAAAATAAACGACGGTGCGCAA
GAAGAAGCAATGGATGAATTGCTCGTGACATTCCAAAAATTAATAAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References