Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1840258..1840787 Replicon chromosome
Accession NZ_CP013943
Organism Staphylococcus epidermidis strain DAR1907

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag SE1UMMC_RS09385 Protein ID WP_001829891.1
Coordinates 1840258..1840620 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag SE1UMMC_RS09390 Protein ID WP_001829931.1
Coordinates 1840617..1840787 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SE1UMMC_RS09365 1837259..1838029 - 771 WP_002468952.1 RNA polymerase sigma factor SigB -
SE1UMMC_RS09370 1838004..1838483 - 480 WP_001829903.1 anti-sigma B factor RsbW -
SE1UMMC_RS09375 1838485..1838811 - 327 WP_001829952.1 anti-sigma factor antagonist -
SE1UMMC_RS09380 1838911..1839912 - 1002 WP_101750561.1 PP2C family protein-serine/threonine phosphatase -
SE1UMMC_RS09385 1840258..1840620 - 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
SE1UMMC_RS09390 1840617..1840787 - 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
SE1UMMC_RS09395 1840874..1842022 - 1149 WP_002468951.1 alanine racemase -
SE1UMMC_RS09400 1842088..1842441 - 354 WP_001829915.1 holo-ACP synthase -
SE1UMMC_RS09405 1842489..1842998 - 510 WP_001829888.1 PH domain-containing protein -
SE1UMMC_RS09410 1842985..1844490 - 1506 WP_001829976.1 PH domain-containing protein -
SE1UMMC_RS09415 1844483..1844962 - 480 WP_001829909.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T59633 WP_001829891.1 NZ_CP013943:c1840620-1840258 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T59633 NZ_CP013943:c1840620-1840258 [Staphylococcus epidermidis]
ATGATTAGAAGAGGAGATGTTTATTTAGCGGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTAGT
TATCATTCAAAATGATACTGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCGATTACTGGTAGGATTAATAAAGCGA
AAATACCAACCCACGTAGAAATTGAAAAGAAAAAGTATAAATTAGACAAAGATTCAGTTATTCTTCTTGAACAAATTAGA
ACACTAGATAAAAAGCGTTTAAAAGAAAAATTAACATTTTTATCAGAGAGTAAAATGATAGAGGTTGATAATGCCTTAGA
TATTAGTTTGGGATTAAATAACTTTGATCATCATAAATCTTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT59633 WP_001829931.1 NZ_CP013943:c1840787-1840617 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT59633 NZ_CP013943:c1840787-1840617 [Staphylococcus epidermidis]
ATGTTATCTTTTAATCAAAATAGAAACCACAGTCTTGAACAATCTTTAAAAGAAGGTTATGCACAAATGGCCGATTTAAA
CCTCTCCCTAGCAACAGAAGCTTTTCCGATAGAGTGTGAAGCTTGTGATTGCAATGAATCACATTTAATATCTAATTCAA
AGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References