Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 6826..8429 Replicon plasmid pCMA1
Accession NZ_CP013941
Organism Cronobacter malonaticus LMG 23826

Toxin (Protein)


Gene name hipA Uniprot ID V5U5S2
Locus tag AFK66_RS20095 Protein ID WP_023897618.1
Coordinates 6826..8145 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag AFK66_RS20100 Protein ID WP_007781034.1
Coordinates 8148..8429 (-) Length 94 a.a.

Genomic Context

AFK66_RS20115AFK66_RS20085AFK66_RS20090AFK66_RS20095AFK66_RS20100AFK66_RS20105AFK66_RS20110
Location: 10790..12538 (1749 bp)
Type: Others
Protein ID: WP_032983474.1
Location: 2207..4738 (2532 bp)
Type: Others
Protein ID: WP_023897681.1
Location: 4735..6519 (1785 bp)
Type: Others
Protein ID: WP_032968604.1
Location: 6826..8145 (1320 bp)
Type: Toxin
Protein ID: WP_023897618.1
Location: 8148..8429 (282 bp)
Type: Antitoxin
Protein ID: WP_007781034.1
Location: 8562..9446 (885 bp)
Type: Others
Protein ID: WP_023897619.1
Location: 9443..10654 (1212 bp)
Type: Others
Protein ID: WP_007780883.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AFK66_RS200852207..4738-2532WP_023897681.1malto-oligosyltrehalose synthase-
AFK66_RS200904735..6519-1785WP_032968604.1malto-oligosyltrehalose trehalohydrolase-
AFK66_RS200956826..8145-1320WP_023897618.1type II toxin-antitoxin system HipA family toxinToxin
AFK66_RS201008148..8429-282WP_007781034.1helix-turn-helix domain-containing proteinAntitoxin
AFK66_RS201058562..9446-885WP_023897619.1siderophore-interacting protein-
AFK66_RS201109443..10654-1212WP_007780883.1MFS transporter-
AFK66_RS2011510790..12538+1749WP_032983474.1aerobactin synthase IucA-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid-iucA / iucB / iucC / iutA / mgtB1..126500126500


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(153-405)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49008.97 Da        Isoelectric Point: 7.2132

>T59629 WP_023897618.1 NZ_CP013941:c8145-6826 [Cronobacter malonaticus LMG 23826]
MRRTSRLALWMNGLPVGYWDKHNGEDRLTYLPEWIADPQGRPLSLSLPFTPGNQSYRGARVRDYFDNLLPDSENIRRRLA
MRYRAQSLEPFDLLAELGRDCVGAIQLLPAGEAPEGLFTIRARPLSTVDIAAMLRHTAEAFPGQHGGEEELRLSIAGAQE
KTALLWHEGQWCLPEGNTPTTHIFKLPLGLVGNMQADMRTSIENEWLCAQLLEAWDIPVARTQMAQFEEQKVLVVERFDR
RLSADGQWWLRLPQEDMCQALGVSPLRKYQADGGPGIGDIMTVLSRSENAQADRANFFRAQIIFWILAATDGHAKNFSIA
HLPGNRYHLTPLYDVLSAWPVIGPGNNQIAWQKCKLAMAVRSGSNYYHLSQIRRRHWLRQGELAGLSAAQVNDMIDALTA
SAPAAIARVAGTLPVDFPASLADVIFNGIRQQCARLAAA

Download         Length: 1320 bp

>T59629 NZ_CP013941:c8145-6826 [Cronobacter malonaticus LMG 23826]
ATGCGCCGCACGTCGCGTTTAGCGCTCTGGATGAACGGCCTCCCGGTCGGCTACTGGGATAAACACAATGGCGAAGACCG
GCTGACCTATCTGCCGGAGTGGATTGCCGATCCGCAAGGGCGGCCGCTGTCGCTGTCGCTGCCGTTCACGCCCGGTAATC
AGTCATACCGCGGCGCGCGGGTGCGCGATTACTTCGACAACCTGCTGCCGGACAGCGAAAACATCCGGCGGCGGCTGGCG
ATGCGCTACCGGGCGCAGAGCCTGGAGCCGTTCGATCTGCTGGCGGAGCTGGGACGCGACTGCGTCGGCGCTATTCAGCT
CCTGCCCGCCGGTGAAGCGCCGGAAGGGCTGTTTACCATCCGCGCCCGTCCACTCTCCACAGTGGATATTGCCGCGATGC
TGCGCCACACCGCAGAGGCGTTCCCCGGCCAGCATGGCGGCGAAGAGGAGCTGCGGCTCTCCATTGCGGGCGCGCAGGAG
AAAACCGCGCTGCTGTGGCACGAAGGCCAGTGGTGCCTGCCGGAGGGCAACACGCCCACCACGCATATTTTCAAACTGCC
GCTGGGGCTGGTGGGCAATATGCAGGCGGACATGCGCACCTCGATTGAAAACGAATGGCTCTGCGCGCAGCTGCTGGAAG
CCTGGGATATTCCGGTCGCGCGCACGCAGATGGCGCAGTTCGAAGAGCAAAAAGTGCTGGTTGTCGAGCGCTTCGACCGG
CGTCTCTCGGCCGATGGCCAGTGGTGGCTGCGTCTGCCGCAGGAGGATATGTGCCAGGCGCTGGGCGTCTCGCCGCTGCG
TAAATATCAGGCCGACGGCGGGCCGGGCATCGGCGATATCATGACGGTTCTGAGCCGTTCAGAAAACGCGCAGGCGGATC
GCGCGAATTTCTTCCGCGCGCAGATTATCTTCTGGATCCTCGCCGCGACCGACGGCCACGCCAAGAATTTCAGCATCGCG
CATCTGCCCGGCAACCGCTACCATCTGACGCCGCTTTACGACGTGCTTTCCGCCTGGCCGGTCATCGGGCCGGGTAATAA
CCAGATTGCGTGGCAGAAGTGCAAGCTGGCGATGGCGGTGCGCAGCGGCAGTAACTATTACCACCTGAGCCAGATCCGCC
GCCGTCACTGGCTGCGCCAGGGCGAGCTTGCCGGGCTGTCGGCGGCGCAGGTCAACGACATGATTGATGCGCTGACAGCC
AGCGCGCCCGCGGCGATCGCGCGCGTGGCCGGCACGCTGCCGGTGGATTTCCCCGCTTCTCTGGCAGACGTTATTTTTAA
CGGCATACGCCAGCAGTGCGCGCGCCTCGCGGCCGCATAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10473.89 Da        Isoelectric Point: 8.0115

>AT59629 WP_007781034.1 NZ_CP013941:c8429-8148 [Cronobacter malonaticus LMG 23826]
MNTHYPLKTLSQLRPLLVGFRKNQGLTQKDVSARLGVTQQTYARLEANPETASIERLFRVFNVLGIEMTLCETQAAEADA
PARDDSPARREAW

Download         Length: 282 bp

>AT59629 NZ_CP013941:c8429-8148 [Cronobacter malonaticus LMG 23826]
ATGAATACCCATTATCCACTGAAAACGCTCAGCCAGCTGCGCCCGCTGCTGGTGGGCTTTCGTAAAAATCAGGGGCTGAC
CCAGAAAGACGTCTCCGCGCGGCTTGGCGTCACGCAGCAAACCTATGCGCGGCTGGAGGCGAACCCCGAGACGGCCAGCA
TTGAGCGCCTGTTCCGCGTCTTTAACGTGCTGGGCATTGAGATGACGCTGTGCGAAACGCAGGCGGCAGAAGCTGACGCG
CCCGCGCGTGACGATTCGCCTGCCCGTCGCGAGGCGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBV5U5S2

Antitoxin

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Source
ID
Structure
No matching records found

References