Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2983596..2984215 Replicon chromosome
Accession NZ_CP013940
Organism Cronobacter malonaticus LMG 23826

Toxin (Protein)


Gene name Hha Uniprot ID V5U1U2
Locus tag AFK66_RS14055 Protein ID WP_007781479.1
Coordinates 2983997..2984215 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V5U2H5
Locus tag AFK66_RS14050 Protein ID WP_007781481.1
Coordinates 2983596..2983970 (+) Length 125 a.a.

Genomic Context

AFK66_RS14040AFK66_RS14045AFK66_RS14050AFK66_RS14055AFK66_RS14060AFK66_RS14065AFK66_RS21555AFK66_RS14070AFK66_RS14075
Location: 2978756..2979961 (1206 bp)
Type: Others
Protein ID: WP_007781488.1
Location: 2979983..2983132 (3150 bp)
Type: Others
Protein ID: WP_007781486.1
Location: 2983596..2983970 (375 bp)
Type: Antitoxin
Protein ID: WP_007781481.1
Location: 2983997..2984215 (219 bp)
Type: Toxin
Protein ID: WP_007781479.1
Location: 2984420..2984971 (552 bp)
Type: Others
Protein ID: WP_007781478.1
Location: 2985092..2985601 (510 bp)
Type: Others
Protein ID: WP_007791512.1
Location: 2985633..2985773 (141 bp)
Type: Others
Protein ID: WP_004386911.1
Location: 2985777..2986037 (261 bp)
Type: Others
Protein ID: WP_004386912.1
Location: 2986177..2988078 (1902 bp)
Type: Others
Protein ID: WP_007781473.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AFK66_RS140402978756..2979961+1206WP_007781488.1multidrug efflux RND transporter periplasmic adaptor subunit AcrA-
AFK66_RS140452979983..2983132+3150WP_007781486.1multidrug efflux RND transporter permease subunit-
AFK66_RS140502983596..2983970+375WP_007781481.1Hha toxicity modulator TomBAntitoxin
AFK66_RS140552983997..2984215+219WP_007781479.1hemolysin expression modulator HhaToxin
AFK66_RS140602984420..2984971+552WP_007781478.1maltose O-acetyltransferase-
AFK66_RS140652985092..2985601+510WP_007791512.1YlaC family protein-
AFK66_RS215552985633..2985773-141WP_004386911.1type B 50S ribosomal protein L36-
AFK66_RS140702985777..2986037-261WP_004386912.1type B 50S ribosomal protein L31-
AFK66_RS140752986177..2988078-1902WP_007781473.1methyl-accepting chemotaxis protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8614.02 Da        Isoelectric Point: 9.4828

>T59626 WP_007781479.1 NZ_CP013940:2983997-2984215 [Cronobacter malonaticus LMG 23826]
MTTKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T59626 NZ_CP013940:2983997-2984215 [Cronobacter malonaticus LMG 23826]
ATGACGACCAAACCATTAACTAAAACCGATTATTTAATGCGACTGAGACGCTGTCAGACAATTGACACGCTTGAGCGCGT
TATTGAAAAAAATAAATATGAATTGTCCGACAATGAACTGGCGGTATTTTATTCAGCAGCGGATCATCGTCTGGCTGAAC
TGACCATGAATAAGCTTTACGATAAAATCCCGACCTCCGTGTGGAAATTCGTTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14357.08 Da        Isoelectric Point: 4.7168

>AT59626 WP_007781481.1 NZ_CP013940:2983596-2983970 [Cronobacter malonaticus LMG 23826]
MDEYSPKRHDIAQLKFLCESLYHDCLATLGENQHGWVNDPTSAVNLQLNDLIEHIASFGLNYKIKHEDDAALIEQLDEYL
DDTFMLFSNYGINAQDLQKWRKSGNRLFRCFINASKENPVSLSF

Download         Length: 375 bp

>AT59626 NZ_CP013940:2983596-2983970 [Cronobacter malonaticus LMG 23826]
ATGGACGAATACTCACCAAAACGGCATGATATAGCGCAGCTTAAATTTCTCTGTGAGAGCCTGTATCATGATTGCCTCGC
CACGCTAGGCGAAAACCAGCATGGCTGGGTTAACGACCCCACTTCCGCCGTTAACCTGCAACTGAACGACCTGATTGAGC
ATATTGCCAGCTTCGGTCTTAATTATAAAATTAAGCATGAAGATGACGCCGCTCTCATTGAACAATTAGATGAATATCTG
GACGATACCTTTATGCTGTTCAGCAATTACGGTATCAATGCGCAAGATTTACAAAAATGGCGCAAGTCCGGAAACAGGCT
TTTCCGGTGTTTCATTAACGCCAGTAAAGAAAATCCTGTGAGCTTGTCTTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBV5U1U2

Antitoxin

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Source
ID
Structure
AlphaFold DBV5U2H5

References