Detailed information of TA system TA059592

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-paaA/RelE(toxin)
• Location: 2650..3100
• Replicon: plasmid pKBN10P02143
• Accession: NZ_CP013925
• Organism: Acinetobacter baumannii strain KBN10P02143

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KBNAB1_RS19745
• Protein ID: WP_059273176.1
• Coordinates: 2825..3100 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: paaA
• Uniprot ID: -
• Locus tag: KBNAB1_RS19740
• Protein ID: WP_004949557.1
• Coordinates: 2650..2838 (+)
• Length: 63 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KBNAB1_RS19725	97..420	-	324	WP_004949566.1	H-NS histone family protein	-
KBNAB1_RS19730	851..1384	+	534	WP_004949563.1	hypothetical protein	-
KBNAB1_RS19735	1832..2530	+	699	WP_004949560.1	DNA adenine methylase	-
KBNAB1_RS19740	2650..2838	+	189	WP_004949557.1	hypothetical protein	Antitoxin
KBNAB1_RS19745	2825..3100	+	276	WP_059273176.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KBNAB1_RS19750	3144..3692	-	549	WP_004949551.1	transglycosylase SLT domain-containing protein	-
KBNAB1_RS19755	3737..6703	-	2967	WP_059273177.1	conjugal transfer protein TraG N-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..52517	52517

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-79)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10438.94 Da
• Isoelectric Point: 5.0825

>T59592 WP_059273176.1 NZ_CP013925:2825-3100 [Acinetobacter baumannii]
MLIVEWTPNAIEDLEAISDYIAEHNPIAAYNLEDHILKCAESLSEHPYKGVSGRVVGTREMLVHPNYWLIYEVSDMIKIK
GVLHTRKSYPD

Nucleotide

• Length: 276 bp

>T59592 NZ_CP013925:2825-3100 [Acinetobacter baumannii]
ATGTTAATCGTTGAGTGGACACCCAACGCTATTGAGGATTTAGAAGCAATTTCAGACTATATAGCTGAACACAATCCTAT
TGCTGCATACAACTTGGAAGATCACATTCTAAAATGCGCTGAAAGCCTATCAGAACATCCATATAAGGGTGTTTCTGGAC
GTGTAGTGGGTACAAGGGAAATGCTGGTACACCCGAACTACTGGCTGATTTATGAAGTCTCAGACATGATCAAAATCAAA
GGCGTACTTCATACTAGAAAATCATATCCGGATTAA

Antitoxin

Protein

• Length: 63 a.a.
• Molecular weight: 7309.13 Da
• Isoelectric Point: 7.2031

>AT59592 WP_004949557.1 NZ_CP013925:2650-2838 [Acinetobacter baumannii]
MNTVFDPIVSEFDSSDHESEYNAWFKAKIEKSMADTRPTVPHDQVVARLKKRREERTTNVNR

Nucleotide

• Length: 189 bp

>AT59592 NZ_CP013925:2650-2838 [Acinetobacter baumannii]
ATGAATACCGTTTTCGATCCTATAGTGTCTGAGTTTGACAGCTCTGATCATGAATCTGAATATAATGCATGGTTCAAAGC
GAAAATTGAAAAATCAATGGCTGATACACGTCCAACTGTACCACACGACCAGGTAGTAGCACGTTTAAAAAAACGTCGTG
AGGAAAGAACAACTAATGTTAATCGTTGA