Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1058188..1058839 Replicon chromosome
Accession NZ_CP013924
Organism Acinetobacter baumannii strain KBN10P02143

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag KBNAB1_RS05165 Protein ID WP_000838146.1
Coordinates 1058188..1058370 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1AAF8
Locus tag KBNAB1_RS05170 Protein ID WP_000966689.1
Coordinates 1058435..1058839 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KBNAB1_RS05120 1053446..1054111 + 666 WP_000767881.1 stress-responsive nuclear envelope protein -
KBNAB1_RS05125 1054116..1054505 + 390 WP_000008492.1 hypothetical protein -
KBNAB1_RS05130 1054507..1054875 + 369 WP_000524231.1 hypothetical protein -
KBNAB1_RS05135 1054884..1055288 + 405 WP_000248324.1 hypothetical protein -
KBNAB1_RS05140 1055260..1055628 + 369 WP_000539752.1 hypothetical protein -
KBNAB1_RS05145 1055630..1056028 + 399 WP_001132270.1 hypothetical protein -
KBNAB1_RS05150 1056030..1056242 + 213 WP_000121166.1 hypothetical protein -
KBNAB1_RS05155 1056350..1057279 + 930 WP_000094300.1 hypothetical protein -
KBNAB1_RS05160 1057324..1057857 + 534 WP_001185622.1 hypothetical protein -
KBNAB1_RS05165 1058188..1058370 + 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
KBNAB1_RS05170 1058435..1058839 + 405 WP_000966689.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KBNAB1_RS05175 1058920..1059321 + 402 WP_000720591.1 hypothetical protein -
KBNAB1_RS05180 1059382..1063347 + 3966 WP_000191304.1 tape measure protein -
KBNAB1_RS05185 1063465..1063806 + 342 WP_001281459.1 phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 972441..1082410 109969


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T59591 WP_000838146.1 NZ_CP013924:1058188-1058370 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T59591 NZ_CP013924:1058188-1058370 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGACGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
CAAACACCCAACCAAAAAGGGATTAGTAACAATCCCTCATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAGCAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14769.78 Da        Isoelectric Point: 4.5000

>AT59591 WP_000966689.1 NZ_CP013924:1058435-1058839 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVSVPDIPGCFSAGDTLYEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT59591 NZ_CP013924:1058435-1058839 [Acinetobacter baumannii]
ATGTTATATCCAATTGCTATTGAAAGAGGTACAGACACCGAAGCCTTTGGTGTCTCCGTTCCAGATATTCCAGGGTGTTT
CAGCGCAGGCGATACATTATATGAAGCTATCGAGAATGTTAAAGAGGCTATTTCTGGCCACTTGGAAATCCTAGCAGAAG
ATGGAGAGGAGATTCCTTTAGCATCTGATGTCAGTAAGTTTATTGACCAAGAAGATTATAGAGGTATGATCTGGGCAGTT
ACTGAAGTTGATGTTAGCCGTTACTTAGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGATTAATTCGGAAGAT
TGATGATAATGTTGGTAAAGATAAAAGATTTAAAACTCGCTCTGCTTTTTTGGCCGCTGGTGCTGAAAAGCTACTACATG
CTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3TWT7

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1AAF8

References