Detailed information of TA system TA059586

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 1607495..1608003
• Replicon: chromosome
• Accession: NZ_CP013922
• Organism: Staphylococcus xylosus strain S170

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: -
• Locus tag: AWC37_RS07925
• Protein ID: WP_029377966.1
• Coordinates: 1607495..1607695 (-)
• Length: 67 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: A0A418I4X8
• Locus tag: AWC37_RS07930
• Protein ID: WP_029377967.1
• Coordinates: 1607710..1608003 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AWC37_RS07910	1602964..1604319	-	1356	WP_081225105.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-
AWC37_RS07915	1604332..1605402	-	1071	WP_038678888.1	D-alanine--D-alanine ligase	-
AWC37_RS07920	1605654..1606859	+	1206	WP_058625514.1	rod shape-determining protein RodA	-
AWC37_RS13870	1607139..1607279	-	141	WP_099265859.1	hypothetical protein	-
AWC37_RS07925	1607495..1607695	-	201	WP_029377966.1	heavy-metal-associated domain-containing protein	Toxin
AWC37_RS07930	1607710..1608003	-	294	WP_029377967.1	copper-sensing transcriptional repressor CsoR	Antitoxin
AWC37_RS07935	1608146..1609630	+	1485	WP_029377968.1	cardiolipin synthase	-
AWC37_RS07940	1609743..1610390	+	648	WP_029377969.1	HD domain-containing protein	-
AWC37_RS07945	1610507..1611376	-	870	WP_029377970.1	membrane protein insertase YidC	-
AWC37_RS07950	1611464..1612102	-	639	WP_081225106.1	thiamine phosphate synthase	-
AWC37_RS07955	1612105..1612893	-	789	WP_038678895.1	hydroxyethylthiazole kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Heavy metal-associated domain, HMA (19-64)

Antitoxin

• Metal-sensitive transcriptional repressor (14-92)

Sequences

Toxin

Protein

• Length: 67 a.a.
• Molecular weight: 7628.68 Da
• Isoelectric Point: 4.3997

>T59586 WP_029377966.1 NZ_CP013922:c1607695-1607495 [Staphylococcus xylosus]
VQSKVIYVSDINSERQYQIKQRLMNVIGVHNVAIDIDKGEILVDFETPASLNNLEKEIYDLGYQIF

Nucleotide

• Length: 201 bp

>T59586 NZ_CP013922:c1607695-1607495 [Staphylococcus xylosus]
GTGCAATCAAAAGTAATTTACGTCTCAGATATTAATTCAGAACGACAATATCAAATAAAACAACGATTAATGAATGTTAT
AGGTGTACACAATGTTGCTATAGATATTGACAAAGGAGAAATACTTGTCGATTTTGAAACACCTGCGAGTTTAAATAATT
TGGAAAAAGAAATTTATGATCTTGGATATCAAATATTTTAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11195.85 Da
• Isoelectric Point: 6.8624

>AT59586 WP_029377967.1 NZ_CP013922:c1608003-1607710 [Staphylococcus xylosus]
VTEIQKAHHSDQIKSNLKSRLNRIEGQVRAINRMVDEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVEKGQQ
EEAMEELLVTFQKLMKD

Nucleotide

• Length: 294 bp

>AT59586 NZ_CP013922:c1608003-1607710 [Staphylococcus xylosus]
GTGACAGAAATACAAAAAGCGCATCATTCAGACCAAATAAAATCAAATTTGAAATCAAGACTAAATAGAATAGAAGGGCA
AGTGCGAGCAATAAACCGTATGGTAGATGAAGATGTTTATTGTGACGATGTACTTACTCAAATTAGAGCGACACGTTCTG
CACTAAATAGCGTAGCAACTAAATTGTTGGATCATCATATGAAAAGTTGCATCATGGATAAAGTGGAAAAAGGTCAACAA
GAAGAAGCAATGGAAGAATTATTAGTAACTTTTCAAAAATTAATGAAGGATTAG

Structures

Antitoxin

• AlphaFold DB: A0A418I4X8