Detailed information of TA system TA059573

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 5092..5534
• Replicon: chromosome
• Accession: NZ_CP013916
• Organism: Sphingomonas sp. LK11

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: AV944_RS00020
• Protein ID: WP_076713788.1
• Coordinates: 5259..5534 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: AV944_RS00015
• Protein ID: WP_056433535.1
• Coordinates: 5092..5271 (+)
• Length: 60 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AV944_RS00010	2701..4959	-	2259	WP_076713786.1	NADP-dependent malic enzyme	-
AV944_RS00015	5092..5271	+	180	WP_056433535.1	hypothetical protein	Antitoxin
AV944_RS00020	5259..5534	+	276	WP_076713788.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AV944_RS00025	5563..8133	+	2571	WP_076717669.1	DNA mismatch repair protein MutS	-
AV944_RS00035	8864..9295	+	432	WP_056433595.1	Rrf2 family transcriptional regulator	-
AV944_RS00040	9465..9917	-	453	WP_056433530.1	large conductance mechanosensitive channel protein MscL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-87)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10298.82 Da
• Isoelectric Point: 5.6864

>T59573 WP_076713788.1 NZ_CP013916:5259-5534 [Sphingomonas sp. LK11]
MARISWSIQASLQLAAIVDYLEEFDPSAARRLGARLLELADSLREFPDPGRPIPQGRREMVTIRPYILRYVHEGDTVVIL
GIRHAAQLSED

Nucleotide

• Length: 276 bp

>T59573 NZ_CP013916:5259-5534 [Sphingomonas sp. LK11]
ATGGCTCGAATAAGCTGGTCGATCCAGGCCTCGCTGCAACTTGCCGCGATCGTCGATTATCTGGAAGAATTCGATCCTTC
TGCAGCCCGGCGATTGGGTGCGCGATTGCTAGAACTCGCTGATTCCCTCCGGGAATTTCCCGATCCCGGCCGACCGATTC
CGCAGGGTCGTCGCGAGATGGTGACGATTCGCCCCTATATTCTGCGTTATGTCCATGAGGGCGATACGGTGGTGATCCTC
GGTATCCGCCATGCCGCCCAACTCTCCGAAGATTGA

Antitoxin

Protein

• Length: 60 a.a.
• Molecular weight: 6989.86 Da
• Isoelectric Point: 4.6234

>AT59573 WP_056433535.1 NZ_CP013916:5092-5271 [Sphingomonas sp. LK11]
MEHEPGIFEQRDEAAELAADERALVDFRAGRFVPHEKMAEWLKTWGTPDRKPLPREWLE

Nucleotide

• Length: 180 bp

>AT59573 NZ_CP013916:5092-5271 [Sphingomonas sp. LK11]
ATGGAGCATGAGCCCGGCATTTTCGAGCAGCGCGACGAGGCGGCGGAACTGGCCGCCGACGAACGCGCGCTTGTGGATTT
TCGGGCCGGCCGTTTCGTGCCGCATGAGAAGATGGCCGAATGGCTGAAGACTTGGGGTACGCCCGATCGCAAGCCCCTGC
CCCGCGAATGGCTCGAATAA